Protein: KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

Gene: KAP2, PRKAR2A
Organism: Homo sapiens
Interactions: 166
UniProt ID: P13861

Gene Ontology (top 5):
GO:0004862 - cAMP-dependent protein kinase inhibitor activity
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568751

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

8

20

Small-scale

0.969

High

568758

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

6

20

High-throughput

0.950

High

568796

AKP13
A-kinase anchor protein 13

7

5

Small-scale

0.950

High

568767

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

5

20

High-throughput

0.927

High

443149

CDK1
Cyclin-dependent kinase 1

3

3

Small-scale

0.857

High

568792

AKA12
A-kinase anchor protein 12

3

5

Small-scale

0.847

High

568862

AKA7G
A-kinase anchor protein 7 isoform gamma

3

8

Small-scale

0.840

High

568756

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

2

20

High-throughput

0.811

High

568803

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

8

High-throughput

0.789

High

568746

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

2

18

Small-scale

0.757

High

568832

AKAP1
A-kinase anchor protein 1, mitochondrial

9

3

Small-scale

0.753

High

568824

AKA28
A-kinase anchor protein 14

6

2

Small-scale

0.738

High

568759

AKAP5
A-kinase anchor protein 5

6

5

Small-scale

0.731

High

568811

MARE1
Microtubule-associated protein RP/EB family member 1

4

3

Small-scale

0.692

High

568777

KC1D
Casein kinase I isoform delta

1

8

High-throughput

0.691

High

568778

KC1E
Casein kinase I isoform epsilon

1

9

High-throughput

0.691

High

568798

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

3

High-throughput

0.691

High

568812

MK06
Mitogen-activated protein kinase 6

1

7

High-throughput

0.691

High

224406

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

8

High-throughput

0.665

High

528981

TAU
Microtubule-associated protein tau

3

7

Small-scale

0.650

High

568814

AKAP4
A-kinase anchor protein 4

1

10

Small-scale

0.647

High

228956

AKAP8
A-kinase anchor protein 8

3

0

Small-scale

0.646

High

240635

PRKN
E3 ubiquitin-protein ligase parkin

3

7

High-throughput

0.640

High

568864

AKA11
A-kinase anchor protein 11

3

5

Small-scale

0.635

High

208459

PJA2
E3 ubiquitin-protein ligase Praja-2

2

1

Small-scale

0.634

High

568841

CK5P2
CDK5 regulatory subunit-associated protein 2

3

10

Small-scale

0.633

High

568843

AKAP9
A-kinase anchor protein 9

3

7

Small-scale

0.631

High

568786

DYL1
Dynein light chain 1, cytoplasmic

2

3

High-throughput

0.628

High

299712

AKAP3
A-kinase anchor protein 3

2

9

Small-scale

0.625

High

568750

KPCA
Protein kinase C alpha type

1

9

High-throughput

0.618

High

568779

GSK3B
Glycogen synthase kinase-3 beta

1

6

Small-scale

0.618

High

568780

KCNQ1
Potassium voltage-gated channel subfamily KQT member 1

1

4

Small-scale

0.618

High

536310

MTAP2
Microtubule-associated protein 2

2

9

Small-scale

0.611

High

568804

RAB32
Ras-related protein Rab-32

2

3

Small-scale

0.594

High

105241

APRIO
Alternative prion protein

3

4

High-throughput

0.585

High

568816

MYOME
Myomegalin

2

10

Small-scale

0.576

High

568805

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

2

High-throughput

0.575

High

395415

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

568781

TERA
Transitional endoplasmic reticulum ATPase

2

1

High-throughput

0.571

High

568870

MTCH2
Mitochondrial carrier homolog 2

2

5

High-throughput

0.571

High

568797

AKAP6
A-kinase anchor protein 6

2

4

Small-scale

0.563

High

568787

RACK1
Small ribosomal subunit protein RACK1

1

4

Small-scale

0.561

High

540296

LAMP1
Lysosome-associated membrane glycoprotein 1

2

0

High-throughput

0.559

High

568867

PLAK2
PALM2-AKAP2 fusion protein

2

4

Small-scale

0.550

High

568854

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

0

Small-scale

0.537

High

174915

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.536

High

289918

OFD1
Centriole and centriolar satellite protein OFD1

1

1

High-throughput

0.536

High

340083

PCNT
Pericentrin

1

6

High-throughput

0.536

High

341893

CEP43
Centrosomal protein 43

1

1

High-throughput

0.536

High

421420

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.536

High

563107

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

568747

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.536

High

568765

CLIP1
CAP-Gly domain-containing linker protein 1

1

2

High-throughput

0.536

High

568770

HSP74
Heat shock 70 kDa protein 4

1

4

High-throughput

0.536

High

568788

TBB4B
Tubulin beta-4B chain

1

3

High-throughput

0.536

High

568801

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.536

High

568844

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

568871

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

3

Small-scale

0.527

High

568795

MTG8
Protein CBFA2T1

1

2

Small-scale

0.523

High

212928

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.513

High

568790

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

270229

MTG16
Protein CBFA2T3

1

2

Small-scale

0.512

High

185398

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.501

High

568830

WASF1
Actin-binding protein WASF1

1

1

Small-scale

0.501

High

370531

FOS
Protein c-Fos

1

1

Small-scale

0.481

High

568776

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.480

High

126451

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.479

High

136813

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

2

High-throughput

0.479

High

172443

XPO1
Exportin-1

1

5

High-throughput

0.479

High

278803

PEX14
Peroxisomal membrane protein PEX14

1

1

High-throughput

0.479

High

315073

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

326509

MFN2
Mitofusin-2

1

1

High-throughput

0.479

High

348341

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

366151

HPT
Haptoglobin

1

1

High-throughput

0.479

High

390853

TRFE
Serotransferrin

1

1

High-throughput

0.479

High

463893

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

4

High-throughput

0.479

High

534576

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

568748

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

568752

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

568753

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

4

High-throughput

0.479

High

568755

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

High-throughput

0.479

High

568757

CBL
E3 ubiquitin-protein ligase CBL

1

4

High-throughput

0.479

High

568760

CCNE1
G1/S-specific cyclin-E1

1

1

Small-scale

0.479

High

568762

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

5

Small-scale

0.479

High

568763

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

568764

CCND3
G1/S-specific cyclin-D3

1

2

Small-scale

0.479

High

568766

GCH1
GTP cyclohydrolase 1

1

1

Small-scale

0.479

High

568769

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

568773

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

568774

INGR2
Interferon gamma receptor 2

1

2

Small-scale

0.479

High

568775

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

568782

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

568783

H4
Histone H4

1

1

High-throughput

0.479

High

568784

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

568785

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

High-throughput

0.479

High

568789

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

568793

CAV1
Caveolin-1

1

2

Small-scale

0.479

High

568794

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

568800

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

568802

CUL3
Cullin-3

1

3

High-throughput

0.479

High

568806

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

2

High-throughput

0.479

High

568807

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

2

Small-scale

0.479

High

568809

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

568819

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

568820

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

568821

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.479

High

568822

MAVS
Mitochondrial antiviral-signaling protein

1

4

High-throughput

0.479

High

568823

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

568825

TAXB1
Tax1-binding protein 1

1

4

High-throughput

0.479

High

568826

MIRO2
Mitochondrial Rho GTPase 2

1

9

High-throughput

0.479

High

568829

DPTOR
DEP domain-containing mTOR-interacting protein

1

1

Small-scale

0.479

High

568831

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

568836

DYL2
Dynein light chain 2, cytoplasmic

1

3

High-throughput

0.479

High

568840

SCLT1
Sodium channel and clathrin linker 1

1

4

High-throughput

0.479

High

568842

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

568845

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.479

High

568846

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

568847

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

568849

RHOJ
Rho-related GTP-binding protein RhoJ

1

4

High-throughput

0.479

High

568850

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

568852

RHOF
Rho-related GTP-binding protein RhoF

1

5

High-throughput

0.479

High

568855

ANLN
Anillin

1

1

High-throughput

0.479

High

568857

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

568858

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

568859

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

568861

MTCH1
Mitochondrial carrier homolog 1

1

4

High-throughput

0.479

High

568863

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

568866

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

3

High-throughput

0.479

High

568868

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

2

High-throughput

0.479

High

568869

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

459430

PROF1
Profilin-1

1

0

High-throughput

0.458

High

568754

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.458

High

568791

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

568813

MIDN
Midnolin

1

0

High-throughput

0.458

High

568818

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

568828

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

568838

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

568856

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

568860

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

568768

1433S
14-3-3 protein sigma

1

5

Small-scale

0.457

High

404649

PRIO
Major prion protein

1

1

High-throughput

0.445

High

429223

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

516378

CALM2
Calmodulin-2

1

3

High-throughput

0.445

High

516460

CALM3
Calmodulin-3

1

3

High-throughput

0.445

High

568771

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

568817

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

568827

POC5
Centrosomal protein POC5

1

1

High-throughput

0.445

High

568839

CEP63
Centrosomal protein of 63 kDa

1

3

High-throughput

0.445

High

568848

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

6

High-throughput

0.445

High

568749

H12
Histone H1.2

1

3

High-throughput

0.437

High

568761

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

568799

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.437

High

568808

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.437

High

568810

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.437

High

568833

ESR2
Estrogen receptor beta

1

6

High-throughput

0.437

High

568834

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

568835

RN125
E3 ubiquitin-protein ligase RNF125

1

8

Small-scale

0.437

High

568851

WDR76
WD repeat-containing protein 76

1

3

High-throughput

0.437

High

568853

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.437

High

568837

C170L
Cep170-like protein

1

1

High-throughput

0.407

High

568815

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

2

0

High-throughput

0.316

High

484357

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

568865

PRDM4
PR domain zinc finger protein 4

1

0

High-throughput

0.279

Low

176324

SYNEM
Synemin

1

0

Small-scale

0.249

Low

568772

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025