HitPredict

Interactor 1: EI2BA (P14741)
Translation initiation factor eIF2B subunit alpha (GCD complex subunit GCN3) (Guanine nucleotide exchange factor subunit GCN3) (Translational activator GCN3) (eIF2B GDP-GTP exchange factor subunit alpha)
Gene: GCN3

Interactor 2: EI2BB (P32502)
Translation initiation factor eIF2B subunit beta (GCD complex subunit GCD7) (Guanine nucleotide exchange factor subunit GCD7) (eIF2B GDP-GTP exchange factor subunit beta)
Gene: GCD7

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.981

The method score is based on:

Property Details
Experiments 11283351, 11805837, 11805826, 16429126, 18719252, 18563728, 20805354, 23263984, 8336705, 18467557, 24852487, 37968396
Identification Methods two hybrid pooling approach, anti tag coimmunoprecipitation, tandem affinity purification, affinity chromatography technology, two hybrid, protein complementation assay, pull down, dihydrofolate reductase reconstruction
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains IF-2B~IF-2B
Common GO terms GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005851 - eukaryotic translation initiation factor 2B complex
and 4 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 305
Sc

1 381
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Dm
+ Sc
+ Dm
+ Hs
+ Ce
+ Hv
+ Sc

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Last updated: 15 Jul 2024