Protein: RHG22
Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22)

Gene: RHG22, ARHGAP22
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q7Z5H3

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

876916

KC1A
Casein kinase I isoform alpha

3

9

High-throughput

0.871

High

877159

KC1D
Casein kinase I isoform delta

2

11

High-throughput

0.811

High

885824

KC1E
Casein kinase I isoform epsilon

2

13

High-throughput

0.811

High

1007722

RAE1L
mRNA export factor RAE1

2

2

High-throughput

0.811

High

1206366

DOC11
Dedicator of cytokinesis protein 11

2

6

High-throughput

0.811

High

1279139

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

2

2

High-throughput

0.811

High

1279144

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

2

8

High-throughput

0.811

High

1279149

DEFI6
Differentially expressed in FDCP 6 homolog

2

19

High-throughput

0.783

High

1206381

FGD3
FYVE, RhoGEF and PH domain-containing protein 3

2

12

High-throughput

0.767

High

955329

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.647

High

962212

RHOA
Transforming protein RhoA

1

20

High-throughput

0.647

High

988484

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.647

High

430088

JUN
Transcription factor Jun

2

7

High-throughput

0.628

High

593148

CREB1
Cyclic AMP-responsive element-binding protein 1

2

1

High-throughput

0.628

High

617104

ATF1
Cyclic AMP-dependent transcription factor ATF-1

2

8

High-throughput

0.628

High

871967

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

4

High-throughput

0.628

High

873474

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

2

5

High-throughput

0.628

High

989910

CANB1
Calcineurin subunit B type 1

2

6

High-throughput

0.628

High

1006147

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

2

4

High-throughput

0.628

High

1091421

ANK3
Ankyrin-3

2

12

High-throughput

0.628

High

1279141

SIR6
NAD-dependent protein deacylase sirtuin-6

2

1

High-throughput

0.628

High

1279142

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

2

4

High-throughput

0.628

High

1279146

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

2

4

High-throughput

0.628

High

194582

KDM6A
Lysine-specific demethylase 6A

2

8

High-throughput

0.611

High

1010759

SSBP2
Single-stranded DNA-binding protein 2

2

0

High-throughput

0.602

High

1279153

DAXX
Death domain-associated protein 6

2

0

High-throughput

0.602

High

143653

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

2

5

High-throughput

0.571

High

175103

SC16A
Protein transport protein Sec16A

2

3

High-throughput

0.571

High

572043

TRI27
Zinc finger protein RFP

2

5

High-throughput

0.571

High

750436

CSTF2
Cleavage stimulation factor subunit 2

2

3

High-throughput

0.571

High

904881

MECP2
Methyl-CpG-binding protein 2

2

3

High-throughput

0.571

High

1119960

CIRBP
Cold-inducible RNA-binding protein

2

3

High-throughput

0.571

High

1279137

PABP2
Polyadenylate-binding protein 2

2

5

High-throughput

0.571

High

1279148

DPY30
Protein dpy-30 homolog

2

1

High-throughput

0.571

High

139718

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

0

High-throughput

0.549

High

332529

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.549

High

900003

FXR1
RNA-binding protein FXR1

1

7

High-throughput

0.541

High

583577

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

5

High-throughput

0.536

High

605084

JUND
Transcription factor JunD

1

6

High-throughput

0.536

High

732635

ARRB2
Beta-arrestin-2

1

3

High-throughput

0.536

High

1272696

MAEA
E3 ubiquitin-protein transferase MAEA

1

3

High-throughput

0.536

High

1279138

ARMC8
Armadillo repeat-containing protein 8

1

2

High-throughput

0.536

High

1279152

IRPL1
Interleukin-1 receptor accessory protein-like 1

1

17

Small-scale

0.527

High

229745

CALU
Calumenin

2

6

High-throughput

0.521

High

1145603

RCN1
Reticulocalbin-1

2

4

High-throughput

0.521

High

1103770

PLD1
Phospholipase D1

1

0

High-throughput

0.517

High

1086253

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.513

High

789156

NUP62
Nuclear pore glycoprotein p62

1

7

High-throughput

0.489

High

1043633

COAA1

1

2

High-throughput

0.489

High

323460

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

910964

IMA1
Importin subunit alpha-1

1

1

High-throughput

0.479

High

973058

RS29
Small ribosomal subunit protein uS14

1

2

High-throughput

0.479

High

1005467

RBM6
RNA-binding protein 6

1

6

High-throughput

0.479

High

1141736

EEA1
Early endosome antigen 1

1

11

High-throughput

0.479

High

1279143

PSPC1
Paraspeckle component 1

1

11

High-throughput

0.479

High

1279145

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

1279150

CCD86
Coiled-coil domain-containing protein 86

1

3

High-throughput

0.479

High

104295

F5H5V6
[histone H3]-trimethyl-L-lysine(27) demethylase

1

5

High-throughput

0.445

High

1279151

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.437

High

1212514

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

2

0

High-throughput

0.328

High

1279140

SRBD1
S1 RNA-binding domain-containing protein 1

2

0

High-throughput

0.328

High

1279147

PDD2L
Programmed cell death protein 2-like

2

0

High-throughput

0.328

High

215749

ERI3
ERI1 exoribonuclease 3

1

0

High-throughput

0.279

Low

1192047

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025