HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0042127 - regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 1342
+	Hs
		383577 PLAK_HUMAN (1-745): 0: 551: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337866 PLAK_HUMAN (1-745): 0: 551: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		383648 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		338023 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		239012 CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		542283 PLAK_HUMAN (1-745): 0: 551: 100.00		ROR1_HUMAN (490-1147): 1.55e-126: 416: 17.37
+	Hs
		337371 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		434143 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		435524 PLAK_HUMAN (1-745): 0: 551: 100.00		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		542198 PLAK_HUMAN (1-745): 0: 551: 100.00		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		542244 PLAK_HUMAN (1-745): 0: 551: 100.00		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		435557 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		665553 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		665156 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		239027 CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Mm
		222829 ARVC_MOUSE (213-739): 8.64e-84: 287: 17.82		ACK1_MOUSE (677-1328): 5.23e-124: 413: 21.75
+	Hs
		239093 CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Mm
		546270 PLAK_MOUSE (1-745): 0: 553: 98.39		INSR_MOUSE (329-650): 4.73e-21: 102: 16.98
+	Rn
		544931 CTNB1_RAT (1-731): 1.13e-173: 519: 67.38		INSR_RAT (329-650): 1.42e-20: 101: 16.71
+	Dm
		382201 ARM_DROME (2-730): 6.94e-161: 488: 60.33		EGFR_DROME (347-637): 4.79e-14: 79.5: 20.27