HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: MAS5 (P25491)
Mitochondrial protein import protein MAS5 (Yeast dnaJ protein 1)
Gene: YDJ1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	32299842, 31399574, 37295430, 37968396, 19536198
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm GO:0051082 - unfolded protein binding and 1 others more... GO:0070482 - response to oxygen levels
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 409
+	Hs
		431571 HS90A_HUMAN (4-705): 0: 1013: 60.67		DNJA1_HUMAN (1-408): 2.99e-150: 432: 45.61
+	Hs
		243260 HS90A_HUMAN (4-705): 0: 1013: 60.67		DNJA2_HUMAN (2-409): 1.74e-143: 416: 45.39
+	Sc
		365867 HSP82_YEAST (1-705): 0: 968: 95.63		MAS5_YEAST (1-409): 1.76e-161: 461: 100.00
+	Hs
		432148 HS90A_HUMAN (4-705): 0: 1013: 60.67		DNJA3_HUMAN (2-398): 1.93e-117: 352: 25.00
+	Dm
		1361622 Q9VAY2_DROME (3-676): 0: 833: 47.09		Q9VFV9_DROME (1-408): 9.18e-131: 383: 43.66
+	Sc
		544207 HSC82_YEAST (1-705): 0: 977: 100.00		APJ1_YEAST (1-353): 1.92e-68: 227: 35.19
+	Sc
		543253 HSC82_YEAST (1-705): 0: 977: 100.00		SCJ1_YEAST (7-350): 5.15e-51: 177: 38.95
+	Sc
		543751 HSC82_YEAST (1-705): 0: 977: 100.00		XDJ1_YEAST (6-354): 3.48e-46: 166: 34.54
+	Rn
		1146018 ENPL_RAT (3-700): 0: 897: 46.34		DJB11_RAT (7-349): 2.88e-49: 172: 36.60
+	Hs
		538434 ENPL_HUMAN (3-680): 0: 893: 47.10		DJB11_HUMAN (7-349): 1.79e-48: 170: 36.60