HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: DOCK1 (Q14185)
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
Gene: DOCK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007264 - small GTPase-mediated signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1865
+	Mm
		925807 RAC1_MOUSE (1-192): 1.69e-84: 249: 92.19		DOCK1_MOUSE (1-1865): 0: 2189: 96.46
+	Hs
		925276 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		925486 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK2_HUMAN (1-1805): 0: 1960: 59.80
+	Hs
		545535 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOCK2_HUMAN (1-1805): 0: 1960: 59.80
+	Hs
		925620 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK5_HUMAN (1-1844): 0: 1934: 62.63
+	Hs
		545622 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOCK5_HUMAN (1-1844): 0: 1934: 62.63
+	Hs
		925425 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		925429 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK4_HUMAN (4-1855): 0: 1748: 36.35
+	Hs
		925588 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK9_HUMAN (231-1004): 0: 654: 14.61
+	Hs
		564671 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		DOCK9_HUMAN (231-1004): 0: 654: 14.61
+	Hs
		545596 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOCK9_HUMAN (231-1004): 0: 654: 14.61
+	Hs
		925332 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOC11_HUMAN (231-999): 0: 602: 13.91
+	Hs
		564557 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		DOC11_HUMAN (231-999): 0: 602: 13.91
+	Hs
		545421 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOC11_HUMAN (231-999): 0: 602: 13.91
+	Hs
		925518 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK6_HUMAN (303-978): 1.07e-138: 480: 11.88
+	Hs
		925526 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK7_HUMAN (736-996): 3.88e-50: 199: 10.47
+	Hs
		925448 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK8_HUMAN (707-1086): 1.69e-39: 164: 9.09
+	Hs
		496789 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		297823 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		K0754_HUMAN (1537-1822): 8.69e-11: 69.8: 10.07
+	Hs
		297812 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		K0754_HUMAN (1537-1822): 8.69e-11: 69.8: 10.07