Interactor 1: EZRI (P15311)
Ezrin (Cytovillin) (Villin-2) (p81)
Gene: EZR

Interactor 2: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.812

The method score is based on:

Property Details
Experiments 10036239, 17891137
Identification Methods affinity chromatography technology, far western blotting, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains ERM_C~ERM_C, ERM_C~FERM_C, ERM_C~FERM_M, ERM_helical~FERM_N, FERM_C~FERM_C, FERM_C~FERM_M, FERM_C~FERM_N, FERM_M~FERM_M, FERM_M~FERM_N, FERM_N~FERM_N
Common GO terms GO:0003779 - actin binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005912 - adherens junction
and 10 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 586
Hs

1 595
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce
+ Ce
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024