Protein: UBA1
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45)

Gene: UBA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 100
UniProt ID: P22515

Gene Ontology (top 5):
GO:0004839 - ubiquitin activating enzyme activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

438521

UBC2
Ubiquitin-conjugating enzyme E2 2

7

20

Small-scale

0.959

High

574773

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

6

20

Small-scale

0.952

High

640544

UBC1
Ubiquitin-conjugating enzyme E2 1

5

20

Small-scale

0.924

High

509404

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

5

17

Small-scale

0.924

High

585681

UBC4
Ubiquitin-conjugating enzyme E2 4

4

20

Small-scale

0.888

High

649480

UBC6
Ubiquitin-conjugating enzyme E2 6

3

20

Small-scale

0.866

High

649516

UBC7
Ubiquitin-conjugating enzyme E2 7

3

20

Small-scale

0.845

High

649475

UBCX
Ubiquitin-conjugating enzyme E2-21 kDa

2

20

Small-scale

0.778

High

649511

UBC13
Ubiquitin-conjugating enzyme E2 13

1

20

High-throughput

0.691

High

649467

UBA1
Ubiquitin-activating enzyme E1 1

1

12

Small-scale

0.647

High

649508

UBC9
SUMO-conjugating enzyme UBC9

1

20

Small-scale

0.647

High

649512

UBC12
NEDD8-conjugating enzyme UBC12

1

20

Small-scale

0.647

High

649483

SERC
Phosphoserine aminotransferase

3

0

High-throughput

0.634

High

649498

SSB2
Ribosome-associated molecular chaperone SSB2

3

10

High-throughput

0.611

High

649488

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.586

High

649505

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

436321

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

9

Small-scale

0.575

High

392248

HSP82
ATP-dependent molecular chaperone HSP82

2

4

High-throughput

0.571

High

394246

EF1A
Elongation factor 1-alpha

2

1

Small-scale

0.571

High

578868

HSC82
ATP-dependent molecular chaperone HSC82

2

4

High-throughput

0.571

High

525949

HSP72
Heat shock protein SSA2

2

11

High-throughput

0.552

High

585589

STI1
Heat shock protein STI1

1

9

High-throughput

0.536

High

624966

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.536

High

649469

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.536

High

649479

HSP79
Heat shock protein homolog SSE2

1

19

High-throughput

0.515

High

649489

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.515

High

449067

CALM
Calmodulin

1

0

High-throughput

0.513

High

560649

KIN2
Serine/threonine-protein kinase KIN2

1

0

High-throughput

0.513

High

649506

CTK3
CTD kinase subunit gamma

1

0

High-throughput

0.513

High

649510

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

649529

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.513

High

649474

HRR25
Casein kinase I homolog HRR25

1

3

High-throughput

0.501

High

649487

CHK1
Serine/threonine-protein kinase CHK1

1

2

High-throughput

0.501

High

649496

KC13
Casein kinase I homolog 3

1

2

High-throughput

0.501

High

649503

SMK1
Sporulation-specific mitogen-activated protein kinase SMK1

1

3

High-throughput

0.501

High

649509

MRK1
Serine/threonine-protein kinase MRK1

1

2

High-throughput

0.501

High

649532

SKS1
Serine/threonine-protein kinase SKS1

1

2

High-throughput

0.501

High

452561

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.493

High

649476

CYS3
Cystathionine gamma-lyase

1

0

High-throughput

0.493

High

649485

NU133
Nucleoporin NUP133

1

0

High-throughput

0.493

High

649486

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.493

High

649493

AURK
Aurora kinase

1

0

High-throughput

0.493

High

649515

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.493

High

649500

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.481

High

649501

MPH1
ATP-dependent DNA helicase MPH1

1

2

Small-scale

0.481

High

649517

ULP1
Ubiquitin-like-specific protease 1

1

2

High-throughput

0.481

High

649533

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.481

High

408288

GAL1
Galactokinase

1

0

High-throughput

0.479

High

518207

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.479

High

604904

MDHM
Malate dehydrogenase, mitochondrial

1

2

Small-scale

0.479

High

646298

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.479

High

649468

KCC2
Calcium/calmodulin-dependent protein kinase II

1

2

High-throughput

0.479

High

649471

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

649473

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

649477

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

649490

ECM29
Proteasome component ECM29

1

1

High-throughput

0.479

High

649495

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

649530

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.479

High

623771

MYO2
Myosin-2

1

0

Small-scale

0.460

High

649481

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

649491

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

649492

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

649514

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

649518

ESP1
Separin

1

0

High-throughput

0.458

High

649519

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

649522

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

649523

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

649526

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

649528

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

368594

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.457

High

453427

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

523089

HSP71
Heat shock protein SSA1

1

11

High-throughput

0.445

High

543848

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

592021

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.445

High

626591

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.445

High

636623

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.445

High

649470

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.445

High

649472

SCJ1
DnaJ-related protein SCJ1

1

2

High-throughput

0.445

High

649478

HSP7F
Heat shock protein homolog SSE1

1

19

High-throughput

0.445

High

649482

PRS7
26S proteasome regulatory subunit 7 homolog

1

4

High-throughput

0.445

High

649484

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.445

High

649494

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.445

High

649504

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.445

High

649507

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.445

High

364935

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

386574

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

486040

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

649499

JEM1
DnaJ-like chaperone JEM1

1

2

High-throughput

0.407

High

649502

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

649524

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

5

High-throughput

0.407

High

649520

YD415
Probable aminopeptidase YDR415C

2

0

High-throughput

0.307

High

649521

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

456334

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.269

Low

649531

RAX2
Bud site selection protein RAX2

1

0

High-throughput

0.269

Low

649513

MPS2
Monopolar spindle protein 2

1

0

Small-scale

0.251

Low

649497

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.249

Low

649525

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

649527

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

575386

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025