Protein: UBA4
Adenylyltransferase and sulfurtransferase UBA4 (Needs CLA4 to survive protein 3) (Ubiquitin-like protein activator 4) [Includes: Adenylyltransferase UBA4 (EC 2.7.7.-); Sulfurtransferase UBA4 (EC 2.8.1.-)]

Gene: UBA4
Organism: Saccharomyces cerevisiae S288C
Interactions: 72
UniProt ID: P38820

Gene Ontology (top 5):
GO:0001403 - invasive growth in response to glucose limitation
GO:0002098 - tRNA wobble uridine modification
GO:0002143 - tRNA wobble position uridine thiolation
GO:0004792 - thiosulfate-cyanide sulfurtransferase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

805347

URM1
Ubiquitin-related modifier 1

7

2

Small-scale

0.974

High

805340

UBA4
Adenylyltransferase and sulfurtransferase UBA4

6

11

Small-scale

0.939

High

805366

THTR
Thiosulfate sulfurtransferase TUM1

1

0

Small-scale

0.656

High

438535

UBC2
Ubiquitin-conjugating enzyme E2 2

1

19

Small-scale

0.647

High

509542

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

14

High-throughput

0.647

High

602451

PHO85
Cyclin-dependent protein kinase PHO85

1

2

High-throughput

0.647

High

640556

UBC1
Ubiquitin-conjugating enzyme E2 1

1

20

Small-scale

0.647

High

750587

UBC6
Ubiquitin-conjugating enzyme E2 6

1

20

Small-scale

0.647

High

526640

HSP72
Heat shock protein SSA2

3

8

High-throughput

0.624

High

748836

SWE1
Mitosis inhibitor protein kinase SWE1

1

4

High-throughput

0.621

High

805356

ATG1
Serine/threonine-protein kinase ATG1

1

2

High-throughput

0.621

High

805341

KOG1
Target of rapamycin complex 1 subunit KOG1

2

1

Small-scale

0.620

High

795332

ATG8
Autophagy-related protein 8

1

6

High-throughput

0.618

High

745272

ELM1
Serine/threonine-protein kinase ELM1

1

0

High-throughput

0.614

High

670685

SIS1
Protein SIS1

2

1

High-throughput

0.584

High

523879

HSP71
Heat shock protein SSA1

2

8

High-throughput

0.571

High

805351

MPS3
Spindle pole body assembly component MPS3

2

0

High-throughput

0.561

High

544800

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.536

High

805355

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

1

Small-scale

0.536

High

805350

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.515

High

805358

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

Small-scale

0.513

High

796392

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

Small-scale

0.501

High

738639

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.486

High

798439

NTM1
Alpha N-terminal protein methyltransferase 1

1

0

High-throughput

0.486

High

805360

MUK1
Protein MUK1

1

0

High-throughput

0.486

High

643636

SNF2
Transcription regulatory protein SNF2

1

1

High-throughput

0.481

High

779536

LHS1
Heat shock protein 70 homolog LHS1

1

10

High-throughput

0.481

High

673376

NFS1
Cysteine desulfurase, mitochondrial

1

0

Small-scale

0.480

High

368660

PMG1
Phosphoglycerate mutase 1

1

2

High-throughput

0.479

High

392700

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

394534

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.479

High

579348

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

585620

STI1
Heat shock protein STI1

1

11

High-throughput

0.479

High

679654

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

727008

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

733656

GLNA
Glutamine synthetase

1

1

High-throughput

0.479

High

760581

TSA1
Peroxiredoxin TSA1

1

4

High-throughput

0.479

High

790196

GLYC
Serine hydroxymethyltransferase, cytosolic

1

2

High-throughput

0.479

High

792034

GBLP
Small ribosomal subunit protein RACK1

1

2

Small-scale

0.479

High

805349

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

4

High-throughput

0.479

High

805369

SGT2
Small glutamine-rich tetratricopeptide repeat-containing protein 2

1

11

High-throughput

0.479

High

780401

RT22
Ribosome assembly protein RSM22, mitochondrial

1

0

High-throughput

0.460

High

780950

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.460

High

805342

SKN7
Transcription factor SKN7

1

0

High-throughput

0.460

High

805359

DID2
Vacuolar protein-sorting-associated protein 46

1

0

High-throughput

0.460

High

805362

ARR1
Arsenical-resistance protein ARR1

1

0

High-throughput

0.460

High

368440

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

531323

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.458

High

805344

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

805352

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.458

High

805364

SGO1
Shugoshin

1

0

High-throughput

0.458

High

805365

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

805370

HSP42
Heat shock protein 42

1

0

High-throughput

0.458

High

805343

MET30
F-box protein MET30

1

3

High-throughput

0.457

High

592232

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.445

High

741537

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

805345

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

707039

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

794828

KMO
Kynurenine 3-monooxygenase

1

1

High-throughput

0.437

High

805346

ULP2
Ubiquitin-like-specific protease 2

1

2

Small-scale

0.437

High

805348

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

799702

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

0

Small-scale

0.287

High

805354

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.265

Low

797172

ATG14
Autophagy-related protein 14

1

0

High-throughput

0.251

Low

805357

CENPQ
Inner kinetochore subunit OKP1

1

0

High-throughput

0.251

Low

805361

KAR5
Nuclear fusion protein KAR5

1

0

High-throughput

0.251

Low

705174

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

805353

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

805363

GIC2
GTPase-interacting component 2

1

0

Small-scale

0.249

Low

805368

HFI1
SAGA complex subunit HFI1

1

0

Small-scale

0.249

Low

805367

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025