Protein: SAE1
SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]

Gene: SAE1
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q9UBE0

Gene Ontology (top 5):
GO:0004839 - ubiquitin activating enzyme activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0008047 - enzyme activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458333

SAE2
SUMO-activating enzyme subunit 2

19

12

Small-scale

0.988

High

993785

UBC9
SUMO-conjugating enzyme UBC9

11

20

Small-scale

0.981

High

964488

SUMO2
Small ubiquitin-related modifier 2

4

10

Small-scale

0.886

High

991447

SUMO1
Small ubiquitin-related modifier 1

2

10

Small-scale

0.799

High

939235

SUMO3
Small ubiquitin-related modifier 3

2

10

High-throughput

0.776

High

243182

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.754

High

182004

UBD
Ubiquitin D

1

13

Small-scale

0.647

High

957538

UBC12
NEDD8-conjugating enzyme Ubc12

1

20

High-throughput

0.618

High

971227

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1458336

UBQL2
Ubiquilin-2

1

2

High-throughput

0.618

High

210136

CRX
Cone-rod homeobox protein

2

1

High-throughput

0.606

High

685371

PAX6
Paired box protein Pax-6

2

2

High-throughput

0.606

High

1037743

PAX5
Paired box protein Pax-5

2

2

High-throughput

0.606

High

1056659

PAX8
Paired box protein Pax-8

2

2

High-throughput

0.606

High

1119617

NFYC
Nuclear transcription factor Y subunit gamma

2

0

High-throughput

0.580

High

1209754

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

290189

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

720707

AGTR1
Type-1 angiotensin II receptor

1

1

High-throughput

0.541

High

1051073

FAK1
Focal adhesion kinase 1

1

4

High-throughput

0.541

High

135725

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.536

High

138779

IMA4
Importin subunit alpha-4

1

4

High-throughput

0.536

High

361368

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

564491

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

832826

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.536

High

911142

IMA1
Importin subunit alpha-1

1

4

High-throughput

0.536

High

922232

CATC
Dipeptidyl peptidase 1

1

2

High-throughput

0.536

High

1134413

IMB1
Importin subunit beta-1

1

1

High-throughput

0.536

High

1458339

TRI35
E3 ubiquitin-protein ligase TRIM35

1

2

High-throughput

0.536

High

464297

FUMH
Fumarate hydratase, mitochondrial

1

1

High-throughput

0.515

High

1038717

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

5

High-throughput

0.515

High

1232617

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

257280

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.513

High

933361

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

1110751

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.513

High

1408515

GDF15
Growth/differentiation factor 15

1

0

High-throughput

0.513

High

1416137

RBM4
RNA-binding protein 4

1

0

High-throughput

0.513

High

1437587

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

0

High-throughput

0.513

High

1458337

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

423376

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

931142

HSP72
Heat shock-related 70 kDa protein 2

1

2

Small-scale

0.501

High

1042935

ERCC6
DNA excision repair protein ERCC-6

1

2

High-throughput

0.501

High

1199475

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

3

Small-scale

0.501

High

701931

ABCD3
ATP-binding cassette sub-family D member 3

1

2

High-throughput

0.489

High

1439077

CPNE5
Copine-5

1

1

High-throughput

0.489

High

894218

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

846939

ETV4
ETS translocation variant 4

1

0

Small-scale

0.480

High

257008

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.479

High

260567

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

279074

TRIM3
Tripartite motif-containing protein 3

1

4

Small-scale

0.479

High

347970

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

373385

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

401638

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

589931

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

607182

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

696750

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

769407

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

775353

FUS
RNA-binding protein FUS

1

2

High-throughput

0.479

High

941078

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

972091

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.479

High

981155

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1033282

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

1050562

UBE3A
Ubiquitin-protein ligase E3A

1

11

High-throughput

0.479

High

1100483

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

1122576

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1151913

RHOH
Rho-related GTP-binding protein RhoH

1

3

High-throughput

0.479

High

1155858

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1255920

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1335027

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

1364644

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1380222

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1397518

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

1434125

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1435401

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1458335

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1458338

HERC5
E3 ISG15--protein ligase HERC5

1

9

Small-scale

0.479

High

1458341

TRAF6
TNF receptor-associated factor 6

1

4

High-throughput

0.479

High

774679

BASI
Basigin

1

2

High-throughput

0.470

High

651002

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.458

High

842668

WASP
Actin nucleation-promoting factor WAS

1

0

Small-scale

0.458

High

879570

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

959284

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

1024908

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1156883

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1359365

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

0

High-throughput

0.458

High

1429381

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1458334

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

330352

VENTX
Homeobox protein VENTX

1

4

High-throughput

0.445

High

414763

P53
Cellular tumor antigen p53

1

1

Small-scale

0.445

High

530501

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

968019

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

Small-scale

0.445

High

1315723

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

1449902

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

1458340

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

412743

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

488882

FURIN
Furin

1

1

High-throughput

0.437

High

1420148

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

1

Small-scale

0.437

High

1438217

RHOF
Rho-related GTP-binding protein RhoF

1

3

High-throughput

0.437

High

598788

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

1292884

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.426

High

1366288

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

1416732

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

887291

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

142432

PEX7
Peroxisomal targeting signal 2 receptor

1

4

High-throughput

0.407

High

628663

CAP7
Azurocidin

1

2

High-throughput

0.407

High

1392420

SYMM
Methionine--tRNA ligase, mitochondrial

1

1

High-throughput

0.407

High

1397187

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

2

High-throughput

0.407

High

1447603

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.407

High

1458342

PCDG9
Protocadherin gamma-A9

1

1

High-throughput

0.407

High

689972

IL3RA
Interleukin-3 receptor subunit alpha

1

0

High-throughput

0.282

High

187812

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.279

Low

1386400

FAF2
FAS-associated factor 2

1

0

High-throughput

0.279

Low

1416844

C1QT2
Complement C1q tumor necrosis factor-related protein 2

1

0

High-throughput

0.279

Low

1161864

CP1B1
Cytochrome P450 1B1

1

0

High-throughput

0.269

Low

164460

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

1194631

DUS28
Dual specificity phosphatase 28

1

0

High-throughput

0.249

Low

1418493

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

1454501

UNC79
Protein unc-79 homolog

1

0

High-throughput

0.249

Low

139338

UPK2
Uroplakin-2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025