HitPredict

Interactor 1: VAV (P15498)
Proto-oncogene vav
Gene: VAV1

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.921

The method score is based on:

Property Details
Experiments 8986718, 8900182, 11331248, 11262396
Identification Methods affinity chromatography technology, pull down, two hybrid, enzymatic study, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~PK_Tyr_Ser-Thr, C1_1~SH2, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, SH2~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007229 - integrin-mediated signaling pathway
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024