HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: DCLK2 (Q8N568)
Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)
Gene: DCLK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005737 - cytoplasm GO:0008017 - microtubule binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 766
+	Mm
		530842 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		DCLK2_MOUSE (1-766): 0: 771: 92.95
+	Hs
		176795 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		DCLK1_HUMAN (1-744): 0: 672: 65.74
+	Mm
		530928 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		DCLK1_MOUSE (1-744): 0: 662: 63.08
+	Hs
		176867 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		DCLK1_HUMAN (1-744): 0: 672: 65.74
+	Hs
		221231 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		DCX_HUMAN (6-354): 1.08e-135: 407: 66.94
+	Hs
		529755 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KCC2B_HUMAN (388-757): 7.35e-131: 405: 33.50
+	Hs
		529756 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KCC2D_HUMAN (388-698): 7.01e-133: 405: 37.46
+	Hs
		530604 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KCC2A_HUMAN (388-712): 1.62e-132: 403: 37.08
+	Hs
		96829 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		E9PBG7_HUMAN (388-748): 1.84e-131: 402: 33.43
+	Rn
		540121 TAU_RAT (1-758): 3.21e-76: 263: 72.11		KCC2A_RAT (388-699): 2.12e-132: 403: 37.98
+	Rn
		469962 TAU_RAT (1-758): 3.21e-76: 263: 72.11		KCC2B_RAT (388-760): 4.77e-131: 402: 33.25
+	Rn
		98663 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		KCC2A_RAT (388-699): 2.12e-132: 403: 37.98
+	Rn
		98655 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		KCC2B_RAT (388-760): 4.77e-131: 402: 33.25
+	Rn
		548656 TAU_RAT (1-758): 3.21e-76: 263: 72.11		KCC2G_RAT (388-697): 2.91e-130: 399: 38.22
+	Rn
		98666 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		KCC2G_RAT (388-697): 2.91e-130: 399: 38.22
+	Mm
		530893 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		KCC2G_MOUSE (388-753): 1.3e-133: 408: 34.87
+	Mm
		631789 MTAP2_MOUSE (26-758): 2.26e-30: 131: 24.41		KCC2D_MOUSE (388-698): 7.01e-133: 405: 37.46
+	Rn
		540202 PCLO_RAT (5-755): 2.91e-16: 85.9: 10.05		KCC2A_RAT (388-699): 2.12e-132: 403: 37.98
+	Hs
		221236 MAP4_HUMAN (22-721): 3.01e-10: 66.2: 9.24		DCX_HUMAN (6-354): 1.08e-135: 407: 66.94