HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: NFKB2 (Q00653)
Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
Gene: NFKB2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25255445
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 900
+	Hs
		1025322 CDK6_HUMAN (5-300): 2.26e-126: 365: 70.03		NFKB2_HUMAN (1-900): 0: 699: 100.00
+	Hs
		443172 CDK1_HUMAN (3-300): 4.42e-129: 370: 42.24		NFKB1_HUMAN (6-881): 0: 561: 40.69
+	Hs
		667798 CDK2_HUMAN (3-301): 2.3e-144: 409: 44.22		REL_HUMAN (33-353): 2.6e-111: 356: 42.37
+	Hs
		549125 CDK4_HUMAN (1-303): 8.01e-128: 367: 100.00		TF65_HUMAN (24-390): 5.26e-112: 356: 37.50
+	Hs
		443314 CDK1_HUMAN (3-300): 4.42e-129: 370: 42.24		RELB_HUMAN (27-356): 2.7e-89: 297: 39.34
+	Hs
		1025325 CDK6_HUMAN (5-300): 2.26e-126: 365: 70.03		RELB_HUMAN (27-356): 2.7e-89: 297: 39.34
+	Hs
		549199 CDK4_HUMAN (1-303): 8.01e-128: 367: 100.00		ANR52_HUMAN (285-608): 5.99e-33: 139: 18.07
+	Hs
		1025481 CDK5_HUMAN (3-301): 3.24e-123: 355: 43.09		MIB1_HUMAN (421-674): 7.63e-24: 110: 23.46