HitPredict - High confidence protein-protein interactions

Interactor 1: VEGFA (P15692)
Vascular endothelial growth factor A, long form (L-VEGF) (Vascular permeability factor) (VPF) [Cleaved into: N-VEGF; VEGFA]
Gene: VEGFA

Interactor 2: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	11486006, 18952601
Identification Methods	electrophoretic mobility shift assay, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0001666 - response to hypoxia GO:0001701 - in utero embryonic development GO:0005634 - nucleus GO:0005737 - cytoplasm and 11 others more... GO:0006357 - regulation of transcription by RNA polymerase II GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression GO:0030335 - positive regulation of cell migration GO:0042803 - protein homodimerization activity GO:0043066 - negative regulation of apoptotic process GO:0045599 - negative regulation of fat cell differentiation GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050927 - positive regulation of positive chemotaxis GO:0051894 - positive regulation of focal adhesion assembly GO:1902894 - negative regulation of miRNA transcription
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	395
Hs

1	425

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024