HitPredict

Interactor 1: DESP (P15924)
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Gene: DSP

Interactor 2: DCAF8 (Q5TAQ9)
DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)
Gene: DCAF8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2871 Hs			1 597
+	Hs
		551777 DESP_HUMAN (1-2871): 0: 818: 100.00		WDTC1_HUMAN (405-597): 4.23e-46: 174: 30.30
+	Hs
		551655 DESP_HUMAN (1-2871): 0: 818: 100.00		WDR5_HUMAN (278-585): 2.83e-45: 165: 12.18
+	Hs
		551728 DESP_HUMAN (1-2871): 0: 818: 100.00		DCAF6_HUMAN (415-576): 1.36e-40: 159: 36.36
+	Hs
		551766 DESP_HUMAN (1-2871): 0: 818: 100.00		WDR5B_HUMAN (466-589): 5.53e-21: 96.2: 15.20
+	Hs
		551747 DESP_HUMAN (1-2871): 0: 818: 100.00		WDR82_HUMAN (329-546): 8.72e-13: 71.4: 10.90
+	Hs
		551854 DESP_HUMAN (1-2871): 0: 818: 100.00		NLE1_HUMAN (86-182): 4.74e-11: 67.2: 8.25
+	Hs
		551632 DESP_HUMAN (1-2871): 0: 818: 100.00		LIS1_HUMAN (505-582): 6.91e-09: 60: 11.54
+	Hs
		1068625 PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33		FBXW7_HUMAN (312-594): 7.67e-52: 191: 12.28
+	Hs
		903240 PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33		WDR5_HUMAN (278-585): 2.83e-45: 165: 12.18
+	Mm
		1132057 MYH4_MOUSE (24-969): 6.75e-35: 149: 8.77		WDTC1_MOUSE (405-597): 3.07e-46: 175: 29.80
+	Hs
		234246 PEPL_HUMAN (1428-2565): 6.62e-28: 126: 14.08		WDTC1_HUMAN (405-597): 4.23e-46: 174: 30.30
+	Hs
		903212 SPTN1_HUMAN (235-2163): 6.27e-28: 126: 9.67		WDR5_HUMAN (278-585): 2.83e-45: 165: 12.18
+	Hs
		903233 GOGB1_HUMAN (1530-2529): 4.77e-20: 101: 9.08		WDR5_HUMAN (278-585): 2.83e-45: 165: 12.18
+	Hs
		522620 MYH7_HUMAN (38-718): 1.99e-21: 105: 8.44		DCAF6_HUMAN (415-576): 1.36e-40: 159: 36.36
+	Mm
		1194831 DYST_MOUSE (245-1057): 1.34e-11: 73.3: 10.33		WDTC1_MOUSE (405-597): 3.07e-46: 175: 29.80
+	Hs
		885220 EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71		WDR5_HUMAN (278-585): 2.83e-45: 165: 12.18
+	Hs
		903137 SPTB2_HUMAN (1169-2330): 8.03e-10: 67.2: 8.93		WDR5_HUMAN (278-585): 2.83e-45: 165: 12.18
+	Hs
		234241 PEPL_HUMAN (1428-2565): 6.62e-28: 126: 14.08		WDR5B_HUMAN (466-589): 5.53e-21: 96.2: 15.20
+	Hs
		792973 CENPE_HUMAN (1293-2534): 2.34e-36: 154: 10.36		LIS1_HUMAN (505-582): 6.91e-09: 60: 11.54
+	Mm
		925837 Q155P7_MOUSE (23-636): 6.99e-16: 87.3: 7.13		LIS1_MOUSE (505-582): 6.49e-09: 60.4: 11.54