Protein: CO4A2
Collagen alpha-2(IV) chain [Cleaved into: Canstatin]

Gene: CO4A2, COL4A2
Organism: Homo sapiens
Interactions: 63
UniProt ID: P08572

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0005587 - collagen type IV trimer
GO:0005201 - extracellular matrix structural constituent
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

471607

C1QT2
Complement C1q tumor necrosis factor-related protein 2

2

20

High-throughput

0.789

High

471606

C1QT1
Complement C1q tumor necrosis factor-related protein 1

2

20

High-throughput

0.776

High

471583

CO8A2
Collagen alpha-2(VIII) chain

2

19

High-throughput

0.754

High

384298

CO4A1

1

16

Small-scale

0.710

High

388761

C1QC
Complement C1q subcomponent subunit C

1

20

High-throughput

0.691

High

471587

COAA1

1

19

High-throughput

0.691

High

471605

COLA1

1

17

High-throughput

0.691

High

471611

COLQ
Acetylcholinesterase collagenic tail peptide

1

19

High-throughput

0.691

High

471584

VHL
von Hippel-Lindau disease tumor suppressor

3

4

Small-scale

0.664

High

469654

MMP2
72 kDa type IV collagenase

3

20

High-throughput

0.662

High

471579

MMP9
Matrix metalloproteinase-9

2

20

High-throughput

0.628

High

471586

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

20

High-throughput

0.628

High

471600

GT252
Procollagen galactosyltransferase 2

2

20

High-throughput

0.628

High

471582

MSRE
Macrophage scavenger receptor types I and II

1

18

High-throughput

0.618

High

388686

C1QB
Complement C1q subcomponent subunit B

1

20

High-throughput

0.618

High

471574

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

1

20

High-throughput

0.618

High

471581

CO9A1

1

16

High-throughput

0.618

High

471588

FGL1
Fibrinogen-like protein 1

2

1

High-throughput

0.611

High

471597

LYG2
Lysozyme g-like protein 2

2

0

High-throughput

0.602

High

251847

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

2

20

High-throughput

0.601

High

471595

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

2

16

High-throughput

0.601

High

471572

CO4A2

1

16

Small-scale

0.575

High

471593

Q4VAQ0
COL8A2 protein

1

20

High-throughput

0.575

High

333741

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

2

5

High-throughput

0.574

High

471578

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

12

High-throughput

0.536

High

378280

IFN21
Interferon alpha-21

1

0

High-throughput

0.513

High

388482

CRP

1

0

High-throughput

0.513

High

471575

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.513

High

471580

ANXA7
Annexin A7

1

5

High-throughput

0.508

High

471585

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

136782

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

3

High-throughput

0.479

High

217736

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

352868

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.479

High

391119

HEMO
Hemopexin

1

20

High-throughput

0.479

High

471589

CUL3
Cullin-3

1

14

High-throughput

0.479

High

471598

TMM25
Transmembrane protein 25

1

1

High-throughput

0.479

High

471609

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.479

High

405380

KITH
Thymidine kinase, cytosolic

1

2

High-throughput

0.464

High

471590

DAZP2
DAZ-associated protein 2

1

1

High-throughput

0.464

High

471592

SMN
Survival motor neuron protein

1

1

High-throughput

0.464

High

60866

COLL1
Colipase-like protein 1

1

0

High-throughput

0.458

High

407829

SEMG1
Semenogelin-1

1

0

High-throughput

0.458

High

467312

CBG
Corticosteroid-binding globulin

1

0

High-throughput

0.458

High

467705

CEL2B
Chymotrypsin-like elastase family member 2B

1

0

High-throughput

0.458

High

471601

ITLN2
Intelectin-2

1

0

High-throughput

0.458

High

469400

ELNE
Neutrophil elastase

1

7

Small-scale

0.457

High

191281

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

12

High-throughput

0.445

High

471602

KLK6
Kallikrein-6

1

5

Small-scale

0.445

High

471603

TET5A
Terminal nucleotidyltransferase 5A

1

1

High-throughput

0.439

High

105158

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

471608

FBX6
F-box only protein 6

1

2

High-throughput

0.437

High

379194

IGHG1
Immunoglobulin heavy constant gamma 1

1

0

High-throughput

0.426

High

471573

ARMS2
Age-related maculopathy susceptibility protein 2

1

1

Small-scale

0.417

High

471594

Q5TF85
polynucleotide adenylyltransferase

1

1

High-throughput

0.417

High

471596

MCAF1
Activating transcription factor 7-interacting protein 1

1

1

High-throughput

0.417

High

471577

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.407

High

471610

FBX2
F-box only protein 2

1

2

High-throughput

0.407

High

471599

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

471604

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

0

High-throughput

0.279

Low

471576

SKIL
Ski-like protein

1

0

High-throughput

0.265

Low

329501

STBD1
Starch-binding domain-containing protein 1

1

0

High-throughput

0.249

Low

471591

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025