HitPredict

Interactor 1: PRP16 (P15938)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13)
Gene: PRP16

Interactor 2: SYF1 (Q04048)
Pre-mRNA-splicing factor SYF1 (PRP19-associated complex protein 90) (Synthetic lethal with CDC40 protein 1)
Gene: SYF1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20089683
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0071007 - U2-type catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1071 Sc			1 859
+	Sc
		589452 PRP2_YEAST (128-984): 0: 856: 36.20		SYF1_YEAST (1-859): 0: 548: 100.00
+	Hs
		1055483 DHX8_HUMAN (65-1013): 0: 780: 36.47		SYF1_HUMAN (30-845): 1.94e-154: 476: 21.48
+	Sc
		622340 PRP22_YEAST (118-1020): 0: 689: 36.83		SYF1_YEAST (1-859): 0: 548: 100.00
+	Hs
		224847 DHX16_HUMAN (113-1007): 0: 716: 36.77		SYF1_HUMAN (30-845): 1.94e-154: 476: 21.48
+	Sc
		554256 PRP16_YEAST (1-1071): 0: 901: 100.00		CLF1_YEAST (4-377): 2.18e-12: 72.7: 11.71
+	Sc
		586358 PRP2_YEAST (128-984): 0: 856: 36.20		PRP6_YEAST (157-799): 5.81e-22: 103: 12.19
+	Hs
		1057967 DHX40_HUMAN (351-1052): 0: 843: 36.41		RRP5_HUMAN (76-379): 2.3e-22: 105: 9.12
+	Sc
		589465 PRP2_YEAST (128-984): 0: 856: 36.20		CLF1_YEAST (4-377): 2.18e-12: 72.7: 11.71
+	Hs
		1160938 DHX40_HUMAN (351-1052): 0: 843: 36.41		CTR9_HUMAN (302-847): 4.99e-12: 71.9: 9.92
+	Hs
		230392 DHX40_HUMAN (351-1052): 0: 843: 36.41		ZC3H1_HUMAN (229-807): 2.13e-09: 63.9: 10.93
+	Hs
		300141 DHX8_HUMAN (65-1013): 0: 780: 36.47		PRP6_HUMAN (459-856): 1.36e-23: 109: 12.94
+	Hs
		994172 DHX9_HUMAN (29-1064): 0: 703: 21.29		SART3_HUMAN (398-838): 1.46e-44: 175: 13.31
+	Hs
		1055399 DHX8_HUMAN (65-1013): 0: 780: 36.47		CTR9_HUMAN (302-847): 4.99e-12: 71.9: 9.92
+	Hs
		1055473 DHX8_HUMAN (65-1013): 0: 780: 36.47		CRNL1_HUMAN (8-269): 3.6e-11: 69.3: 18.80
+	Hs
		230362 DHX8_HUMAN (65-1013): 0: 780: 36.47		ZC3H1_HUMAN (229-807): 2.13e-09: 63.9: 10.93
+	Hs
		1063230 DHX57_HUMAN (29-1064): 0: 635: 21.23		SART3_HUMAN (398-838): 1.46e-44: 175: 13.31
+	Sc
		859429 PRP43_YEAST (257-1011): 0: 671: 39.79		RRP5_YEAST (572-839): 8.35e-22: 104: 15.96
+	Sp
		194928 DHX15_SCHPO (281-995): 0: 683: 40.63		CLF1_SCHPO (645-858): 1.89e-14: 79.7: 14.82
+	Sc
		622351 PRP22_YEAST (118-1020): 0: 689: 36.83		CLF1_YEAST (4-377): 2.18e-12: 72.7: 11.71
+	Sc
		859463 PRP43_YEAST (257-1011): 0: 671: 39.79		CLF1_YEAST (4-377): 2.18e-12: 72.7: 11.71