HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: MACD1 (Q9BQ69)
ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)
Gene: MACROD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 325
+	Hs
		260743 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		H2AY_HUMAN (121-314): 1.57e-51: 176: 22.11
+	Hs
		260706 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		H2AY_HUMAN (121-314): 1.57e-51: 176: 22.11
+	Hs
		260729 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		H2AY_HUMAN (121-314): 1.57e-51: 176: 22.11
+	Hs
		260900 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		H2AY_HUMAN (121-314): 1.57e-51: 176: 22.11
+	Hs
		1216276 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		H2AW_HUMAN (131-314): 4.06e-45: 159: 19.70
+	Hs
		391940 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		H2AW_HUMAN (131-314): 4.06e-45: 159: 19.70
+	Hs
		470593 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		H2AW_HUMAN (131-314): 4.06e-45: 159: 19.70
+	Hs
		261026 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		H2AW_HUMAN (131-314): 4.06e-45: 159: 19.70