HitPredict

Interactor 1: TRI27 (P14373)
Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27)
Gene: TRIM27

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	31747314, 15907835
Identification Methods	affinity chromatography technology, enzymatic study, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0016925 - protein sumoylation GO:0019789 - SUMO transferase activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 513 Hs			1 628
+	Hs
		297434 TRI27_HUMAN (1-513): 2.46e-175: 505: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297743 TRI27_HUMAN (1-513): 2.46e-175: 505: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		297685 TRIM5_HUMAN (1-494): 1.63e-123: 372: 28.65		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		297713 TRI35_HUMAN (3-492): 2.78e-102: 317: 26.45		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		572066 TRI27_HUMAN (1-513): 2.46e-175: 505: 100.00		PIAS4_HUMAN (2-477): 2.12e-177: 514: 46.71
+	Hs
		297833 TRI50_HUMAN (1-487): 2.72e-118: 358: 27.70		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		142689 TRI38_HUMAN (1-494): 2.73e-130: 388: 32.60		PIAS4_HUMAN (2-477): 2.12e-177: 514: 46.71