HitPredict

Interactor 1: KPYM (P14618)
Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Threonine-protein kinase PKM2) (EC 2.7.11.1) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (Tyrosine-protein kinase PKM2) (EC 2.7.10.2) (p58)
Gene: PKM

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37746908
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 531 Hs			1 522
+	Mm
		912287 KPYM_MOUSE (1-531): 0: 783: 97.74		TRAF6_MOUSE (1-522): 1.79e-139: 414: 87.93
+	Hs
		573229 KPYM_HUMAN (1-531): 0: 801: 100.00		TRAF4_HUMAN (54-500): 7.12e-89: 282: 26.11
+	Hs
		323147 KPYM_HUMAN (1-531): 0: 801: 100.00		TRI37_HUMAN (56-501): 7.26e-47: 177: 13.89
+	Hs
		573176 KPYM_HUMAN (1-531): 0: 801: 100.00		TRI58_HUMAN (62-410): 1.05e-48: 177: 13.17
+	Hs
		572982 KPYM_HUMAN (1-531): 0: 801: 100.00		RO52_HUMAN (64-411): 3.76e-48: 175: 15.24
+	Hs
		573098 KPYM_HUMAN (1-531): 0: 801: 100.00		TRI25_HUMAN (63-370): 4.82e-45: 169: 18.61
+	Hs
		573236 KPYM_HUMAN (1-531): 0: 801: 100.00		TRI31_HUMAN (58-334): 2.83e-35: 138: 15.00
+	Hs
		1348602 V9HWB8_HUMAN (1-531): 0: 801: 100.00		LNX1_HUMAN (58-183): 2.6e-11: 68.3: 19.84
+	Hs
		573178 KPYM_HUMAN (1-531): 0: 801: 100.00		LNX1_HUMAN (58-183): 2.6e-11: 68.3: 19.84