HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: HSP13 (P48723)
Heat shock 70 kDa protein 13 (Heat shock protein family A member 13) (Microsomal stress-70 protein ATPase core) (Stress-70 protein chaperone microsome-associated 60 kDa protein)
Gene: HSPA13

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.793

The method score is based on:

Property Details
Experiments 33957083, 35914814
Identification Methods proximity labelling technology, two hybrid, two hybrid fragment pooling approach
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains HATPase_c_3~HSP70, HSP70~HSP90
Common GO terms GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0016887 - ATP hydrolysis activity
and 3 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 803
Hs

1 471
+ Hs
+ Hs
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+ Gg
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Gg
+ Ce
+ Sc
+ Sc
+ Sc
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+ Sc

Service provided by Combinatics, Japan

Last updated: 11Aug2025