HitPredict

Interactor 1: PTC (P18502)
Protein patched (Hedgehog receptor)
Gene: PTC

Interactor 2: NEDD4 (Q9VVI3)
E3 ubiquitin-protein ligase Nedd-4 (DNedd4) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4)
Gene: NEDD4

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.677

Property	Details
Experiments	16980583, 24302888, 29438012, 15710747
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007411 - axon guidance GO:0045879 - negative regulation of smoothened signaling pathway
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1286 Dm			1 1007
+	Hs
		1044417 PTC1_HUMAN (24-1261): 0: 1165: 37.25		NED4L_HUMAN (63-1007): 0: 904: 47.53
+	Dm
		577424 PTC_DROME (1-1286): 0: 1295: 100.00		SUDX_DROME (70-1003): 0: 734: 29.72
+	Hs
		808120 PTC1_HUMAN (24-1261): 0: 1165: 37.25		NEDD4_HUMAN (150-1007): 0: 770: 47.57
+	Hs
		1044412 PTC1_HUMAN (24-1261): 0: 1165: 37.25		ITCH_HUMAN (56-1004): 0: 757: 29.56
+	Hs
		1044434 PTC1_HUMAN (24-1261): 0: 1165: 37.25		WWP1_HUMAN (60-1004): 0: 750: 30.85
+	Hs
		125442 PTC1_HUMAN (24-1261): 0: 1165: 37.25		WWP2_HUMAN (289-1004): 0: 685: 35.40
+	Dm
		577410 PTC_DROME (1-1286): 0: 1295: 100.00		Q9VXR3_DROME (482-1005): 5.13e-155: 511: 33.52
+	Hs
		168007 NPC1_HUMAN (59-1111): 0: 736: 18.69		NED4L_HUMAN (63-1007): 0: 904: 47.53
+	Hs
		167863 NPC1_HUMAN (59-1111): 0: 736: 18.69		NEDD4_HUMAN (150-1007): 0: 770: 47.57
+	Hs
		168027 NPC1_HUMAN (59-1111): 0: 736: 18.69		WWP1_HUMAN (60-1004): 0: 750: 30.85
+	Dm
		577378 PTC_DROME (1-1286): 0: 1295: 100.00		SMUF1_DROME (69-621): 1.71e-32: 138: 15.37
+	Hs
		1044440 PTC1_HUMAN (24-1261): 0: 1165: 37.25		SMUF2_HUMAN (71-464): 1.04e-30: 131: 16.88
+	Hs
		1044442 PTC1_HUMAN (24-1261): 0: 1165: 37.25		SMUF1_HUMAN (66-439): 1.08e-27: 122: 16.08