HitPredict - High confidence protein-protein interactions

Interactor 1: ATF4 (P18848)
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)
Gene: ATF4

Interactor 2: DDIT3 (P35638)
DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)
Gene: DDIT3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	23661758, 18330356, 20038797, 20102225
Identification Methods	fluorescent resonance energy transfer, two hybrid, anti tag coimmunoprecipitation, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific and 23 others more... GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription GO:0006357 - regulation of transcription by RNA polymerase II GO:0008140 - cAMP response element binding protein binding GO:0030968 - endoplasmic reticulum unfolded protein response GO:0034976 - response to endoplasmic reticulum stress GO:0036499 - PERK-mediated unfolded protein response GO:0043522 - leucine zipper domain binding GO:0043525 - positive regulation of neuron apoptotic process GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0090575 - RNA polymerase II transcription regulator complex GO:0120163 - negative regulation of cold-induced thermogenesis GO:0140467 - integrated stress response signaling GO:1990617 - CHOP-ATF4 complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	351
Hs

1	169

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Last updated: 15 Jul 2024