Protein: SYG
Glycine--tRNA ligase 1, mitochondrial (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase 1) (GlyRS 1) (GlyRS1)

Gene: SYG, GRS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 96
UniProt ID: P38088

Gene Ontology (top 5):
GO:0004820 - glycine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416113

SYTC
Threonine--tRNA ligase, cytoplasmic

1

9

High-throughput

0.618

High

454162

SYH
Histidine--tRNA ligase, mitochondrial

1

2

High-throughput

0.618

High

793318

YHI0
Putative proline--tRNA ligase YHR020W

1

9

High-throughput

0.618

High

793352

SYG2
Glycine--tRNA ligase 2

1

9

High-throughput

0.618

High

726956

HS104
Heat shock protein 104

2

4

Small-scale

0.584

High

793332

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

793358

RRP6
Exosome complex exonuclease RRP6

2

3

High-throughput

0.558

High

793359

HRT3
F-box protein HRT3

1

0

Small-scale

0.549

High

793324

RV167
Reduced viability upon starvation protein 167

1

10

High-throughput

0.536

High

793331

EMW1
Essential for maintenance of the cell wall protein 1

1

2

High-throughput

0.536

High

793343

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

793351

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.513

High

793316

KSP1
Serine/threonine-protein kinase KSP1

1

3

High-throughput

0.501

High

625000

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.489

High

748162

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

High-throughput

0.489

High

793337

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.489

High

368890

SYMC
Methionine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.479

High

392595

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.479

High

394475

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.479

High

416225

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

435031

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

435917

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

452885

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

514599

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.479

High

544572

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.479

High

558684

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

560796

SYQ
Glutamine--tRNA ligase

1

6

High-throughput

0.479

High

579244

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

581852

SYKC
Lysine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

594330

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

Small-scale

0.479

High

657079

IF5A1
Eukaryotic translation initiation factor 5A-1

1

4

High-throughput

0.479

High

671921

RBSK
Ribokinase

1

1

High-throughput

0.479

High

674573

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

679593

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

687582

SYLC
Leucine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.479

High

746818

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

1

High-throughput

0.479

High

750636

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

778282

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

779042

EF1G2
Elongation factor 1-gamma 2

1

4

High-throughput

0.479

High

793315

ATG8
Autophagy-related protein 8

1

5

High-throughput

0.479

High

793317

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

793319

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.479

High

793322

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.479

High

793330

MMM1
Maintenance of mitochondrial morphology protein 1

1

1

High-throughput

0.479

High

793333

LSB3
LAS seventeen-binding protein 3

1

7

High-throughput

0.479

High

793335

HOSC
Homocitrate synthase, cytosolic isozyme

1

3

High-throughput

0.479

High

793338

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

793340

SPC98
Spindle pole body component SPC98

1

2

High-throughput

0.479

High

793341

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

2

High-throughput

0.479

High

793342

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

793348

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

2

High-throughput

0.479

High

793355

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

793356

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

1

High-throughput

0.479

High

793360

DBP10
ATP-dependent RNA helicase DBP10

1

7

High-throughput

0.479

High

793361

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

670599

SIS1
Protein SIS1

1

3

High-throughput

0.470

High

382888

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

618946

IRA2
Inhibitory regulator protein IRA2

1

0

Small-scale

0.458

High

646377

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

745709

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

782157

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

793325

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.458

High

736844

APE2
Aminopeptidase 2, mitochondrial

1

2

High-throughput

0.445

High

762947

SPT7
SAGA complex subunit SPT7

1

1

High-throughput

0.445

High

793326

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

793354

SSK1
Osmolarity two-component system protein SSK1

1

2

High-throughput

0.445

High

793327

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.439

High

793345

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.439

High

441864

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

502999

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

512962

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

619159

IF5A2
Eukaryotic translation initiation factor 5A-2

1

4

High-throughput

0.437

High

706867

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

736376

MET4
Transcriptional activator of sulfur metabolism MET4

1

2

High-throughput

0.437

High

753323

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

793314

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

793320

RPN10
26S proteasome regulatory subunit RPN10

1

2

High-throughput

0.437

High

793323

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

793328

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

793329

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

793336

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.437

High

793347

YMC0
Uncharacterized protein YML020W

1

2

High-throughput

0.437

High

793350

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

793353

NVJ2
Nucleus-vacuole junction protein 2

1

1

High-throughput

0.437

High

793357

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

793362

RKM4
Ribosomal lysine N-methyltransferase 4

1

1

High-throughput

0.437

High

597731

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

793313

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

5

High-throughput

0.407

High

793346

GCN5
Histone acetyltransferase GCN5

1

2

High-throughput

0.407

High

758202

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.249

Low

780735

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

793339

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

Small-scale

0.249

Low

793349

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

793321

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

793334

GWT1
GPI-anchored wall transfer protein 1

1

0

High-throughput

0.232

Low

793344

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025