HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: PPIA (P62937)
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Gene: PPIA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31871319, 38943005
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pro_isomerase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 165
+	Hs
		986323 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		719422 RHOG_HUMAN (1-192): 5.1e-79: 235: 70.83		PPIF_HUMAN (3-164): 6.29e-92: 267: 76.54
+	Hs
		953381 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		986341 RHOG_HUMAN (1-192): 5.1e-79: 235: 70.83		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		955034 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		961931 RHOA_HUMAN (5-192): 1.59e-77: 231: 54.26		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		962637 RHOA_HUMAN (5-192): 1.59e-77: 231: 54.26		PPIE_HUMAN (2-163): 2.09e-88: 262: 67.28
+	Hs
		466195 RHOC_HUMAN (5-192): 3.56e-75: 225: 54.79		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00