HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: PPIA (P62937)
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Gene: PPIA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pro_isomerase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0031982 - vesicle GO:0070062 - extracellular exosome
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 193 Hs			1 165
+	Hs
		962637 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		PPIE_HUMAN (2-163): 2.09e-88: 262: 67.28
+	Hs
		986323 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		719422 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		PPIF_HUMAN (3-164): 6.29e-92: 267: 76.54
+	Hs
		466195 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		986341 RHOG_HUMAN (1-193): 1.49e-76: 229: 54.40		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		955034 CDC42_HUMAN (1-193): 4.17e-76: 228: 52.33		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		580976 RAC2_HUMAN (1-193): 2.82e-75: 226: 53.61		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		953381 RAC3_HUMAN (1-179): 3.87e-73: 220: 57.54		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		977914 RHOB_HUMAN (1-191): 9.8e-73: 219: 83.94		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00
+	Hs
		126538 RHOD_HUMAN (7-182): 1.69e-69: 212: 53.98		PPIA_HUMAN (1-165): 2.79e-91: 264: 100.00