HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.936

Property	Details
Experiments	7706237, 11390650, 16467851, 21725281, 15929943
Identification Methods	pull down, affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	C2~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005911 - cell-cell junction GO:0050852 - T cell receptor signaling pathway
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1290 Hs			1 533
+	Mm
		1141377 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		581031 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Mm
		1208607 PLCG2_MOUSE (19-1287): 0: 1131: 50.12		BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27
+	Hs
		562659 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Mm
		536209 FGR_MOUSE (438-661): 1.26e-19: 96.2: 18.18		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57