HitPredict

Interactor 1: EPOR (P19235)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	7534299, 8647802, 9129019
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 217
+	Mm
		540268 EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		581163 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74
+	Hs
		500956 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		548635 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		433567 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522759 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		540265 EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47
+	Hs
		540459 IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		562545 IL7RA_HUMAN (109-477): 4.76e-65: 219: 15.65		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		682260 IL2RG_HUMAN (15-351): 3.88e-59: 201: 17.35		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924483 IL5RA_HUMAN (24-301): 7.09e-53: 186: 18.31		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924809 CSF3R_HUMAN (14-425): 2.42e-50: 186: 13.92		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		500941 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		411578 IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		548629 PRLR_HUMAN (40-499): 4.21e-85: 276: 18.03		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		560471 PRLR_HUMAN (40-499): 4.21e-85: 276: 18.03		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18
+	Mm
		411919 CSF3R_MOUSE (14-399): 4.44e-42: 162: 15.08		LCK_MOUSE (3-202): 2.89e-37: 137: 28.44
+	Hs
		411991 IL7RA_HUMAN (109-477): 4.76e-65: 219: 15.65		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		442875 CSF3R_HUMAN (14-425): 2.42e-50: 186: 13.92		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433961 CSF3R_HUMAN (14-425): 2.42e-50: 186: 13.92		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47