HitPredict

Interactor 1: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Interactor 2: CSK21 (P68400)
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Gene: CSNK2A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	35271311, 30855574, 22113938
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type	physical association, direct interaction, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0017148 - negative regulation of translation
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 710 Hs			1 391
+	Hs
		582057 NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00		CSK22_HUMAN (1-334): 4.14e-119: 351: 85.08
+	Hs
		582140 NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00		GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12
+	Hs
		516457 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00
+	Hs
		934135 PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88		CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00
+	Hs
		642759 ELAV4_HUMAN (464-709): 5.73e-44: 164: 18.82		CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00
+	Sc
		376615 PABP_YEAST (181-555): 3.61e-53: 194: 17.47		CSK21_YEAST (1-329): 6.88e-113: 336: 54.32
+	Hs
		516362 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		CDK2_HUMAN (36-330): 5.34e-122: 356: 29.74
+	Hs
		516419 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		GSK3B_HUMAN (39-389): 1.2e-112: 337: 29.12