Protein: PI3R4
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)

Gene: PI3R4, PIK3R4
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q99570

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005770 - late endosome
GO:0005776 - autophagosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1243070

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

11

8

Small-scale

0.977

High

929625

RACK1
Small ribosomal subunit protein RACK1

2

11

Small-scale

0.834

High

1120077

FND3B
Fibronectin type III domain-containing protein 3B

2

5

High-throughput

0.783

High

1054192

BECN1
Beclin-1

17

3

Small-scale

0.764

High

1169287

BAKOR
Beclin 1-associated autophagy-related key regulator

16

1

Small-scale

0.762

High

1290846

NRBF2
Nuclear receptor-binding factor 2

10

2

Small-scale

0.758

High

151156

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

20

Small-scale

0.754

High

172197

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.691

High

636402

DNJB1
DnaJ homolog subfamily B member 1

1

5

High-throughput

0.691

High

735001

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

19

High-throughput

0.691

High

921945

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.691

High

1304597

DNAI2
Dynein axonemal intermediate chain 2

1

7

High-throughput

0.691

High

1304602

PAR6A
Partitioning defective 6 homolog alpha

1

11

High-throughput

0.691

High

1304607

UVRAG
UV radiation resistance-associated gene protein

4

1

Small-scale

0.691

High

1268407

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

4

1

Small-scale

0.683

High

1304610

HECD1
E3 ubiquitin-protein ligase HECTD1

2

14

High-throughput

0.675

High

1264789

TITIN
Titin

1

6

High-throughput

0.665

High

909952

1433E
14-3-3 protein epsilon

3

15

Small-scale

0.633

High

943426

TCPB
T-complex protein 1 subunit beta

2

16

High-throughput

0.628

High

1304601

PACER
Protein associated with UVRAG as autophagy enhancer

2

1

High-throughput

0.628

High

723386

APJ
Apelin receptor

1

1

High-throughput

0.618

High

1031058

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

2

High-throughput

0.618

High

1039797

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.618

High

1202717

P2RY8
P2Y purinoceptor 8

1

2

High-throughput

0.618

High

1304612

GPR55
G-protein coupled receptor 55

1

4

High-throughput

0.618

High

228464

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.618

High

338884

EGFR
Epidermal growth factor receptor

1

5

Small-scale

0.618

High

385404

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.618

High

592453

RAB5A
Ras-related protein Rab-5A

1

11

High-throughput

0.618

High

787549

MTOR
Serine/threonine-protein kinase mTOR

1

15

Small-scale

0.618

High

803710

BAG6
Large proline-rich protein BAG6

1

7

High-throughput

0.618

High

845195

RAB7A
Ras-related protein Rab-7a

1

10

High-throughput

0.618

High

845691

RAB9A
Ras-related protein Rab-9A

1

9

High-throughput

0.618

High

850165

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

Small-scale

0.618

High

1153727

STYK1
Tyrosine-protein kinase STYK1

1

6

Small-scale

0.618

High

1273824

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

High-throughput

0.618

High

1304598

Q9H4D1
Protein kinase

1

6

High-throughput

0.618

High

683659

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.601

High

196657

ZBT24
Zinc finger and BTB domain-containing protein 24

1

4

High-throughput

0.595

High

310411

EPM2A
Laforin

1

0

Small-scale

0.586

High

905029

1433G
14-3-3 protein gamma

2

20

High-throughput

0.584

High

1304608

ZRAN1
Ubiquitin thioesterase ZRANB1

2

7

High-throughput

0.584

High

883615

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.575

High

1269442

ESR2
Estrogen receptor beta

2

11

High-throughput

0.571

High

131839

KRIT1
Krev interaction trapped protein 1

1

4

Small-scale

0.553

High

1171384

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.553

High

1304599

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

207097

XRCC3
DNA repair protein XRCC3

1

2

High-throughput

0.536

High

428381

TBB5
Tubulin beta chain

1

2

High-throughput

0.536

High

505461

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

7

High-throughput

0.536

High

573435

TCPA
T-complex protein 1 subunit alpha

1

12

High-throughput

0.536

High

575151

RL7
Large ribosomal subunit protein uL30

1

3

High-throughput

0.536

High

644139

EF1G
Elongation factor 1-gamma

1

5

High-throughput

0.536

High

684973

STIP1
Stress-induced-phosphoprotein 1

1

12

High-throughput

0.536

High

770999

TCPZ
T-complex protein 1 subunit zeta

1

13

High-throughput

0.536

High

813697

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

821377

TCPE
T-complex protein 1 subunit epsilon

1

15

High-throughput

0.536

High

826838

TCPG
T-complex protein 1 subunit gamma

1

15

High-throughput

0.536

High

843009

TCPQ
T-complex protein 1 subunit theta

1

19

High-throughput

0.536

High

843347

TCPD
T-complex protein 1 subunit delta

1

11

High-throughput

0.536

High

1023222

FLII
Protein flightless-1 homolog

1

6

High-throughput

0.536

High

1283448

SPSB4
SPRY domain-containing SOCS box protein 4

1

13

High-throughput

0.536

High

1304595

TCPH
T-complex protein 1 subunit eta

1

15

High-throughput

0.536

High

1304609

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.536

High

1304606

RRBP1
Ribosome-binding protein 1

1

13

High-throughput

0.515

High

319041

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

417097

KCRM
Creatine kinase M-type

1

0

High-throughput

0.513

High

901730

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.513

High

1303985

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

1304604

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.513

High

1304613

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

1120306

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.493

High

441632

TRFM
Melanotransferrin

1

1

High-throughput

0.489

High

1231194

KLH34
Kelch-like protein 34

1

1

High-throughput

0.489

High

163180

XPO1
Exportin-1

1

14

High-throughput

0.479

High

323041

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.479

High

455790

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

527741

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

567235

CXA1
Gap junction alpha-1 protein

1

2

Small-scale

0.479

High

638181

PSA4
Proteasome subunit alpha type-4

1

4

High-throughput

0.479

High

982420

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1085338

FSCN1
Fascin

1

1

High-throughput

0.479

High

1243899

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

1304596

MLP3C
Microtubule-associated proteins 1A/1B light chain 3C

1

6

High-throughput

0.479

High

1304600

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1304611

MARE3
Microtubule-associated protein RP/EB family member 3

1

1

High-throughput

0.479

High

526031

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

1304605

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

205877

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.437

High

347686

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.437

High

721246

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1086287

H31T
Histone H3.1t

1

12

High-throughput

0.437

High

255189

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.426

High

1241584

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

1304603

JADE2
E3 ubiquitin-protein ligase Jade-2

3

0

High-throughput

0.347

High

246027

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.279

Low

1254638

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1152057

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

886325

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024