HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: GRK6 (P43250)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 455 Hs			1 576
+	Hs
		584382 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		KPCD_HUMAN (9-518): 2.81e-144: 434: 24.86
+	Hs
		584328 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		AKT1_HUMAN (75-497): 3.54e-143: 424: 30.59
+	Mm
		554864 TNR1A_MOUSE (1-445): 4.25e-127: 377: 64.37		KPCE_MOUSE (11-507): 3.24e-148: 445: 24.28
+	Hs
		794440 EDAR_HUMAN (27-450): 4e-77: 249: 14.32		GRK6_HUMAN (1-576): 0: 573: 100.00
+	Mm
		626850 TNR1A_MOUSE (1-445): 4.25e-127: 377: 64.37		KPCD_MOUSE (9-517): 2.55e-147: 441: 24.90
+	Hs
		408551 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		KPCB_HUMAN (191-498): 2.23e-57: 205: 38.07
+	Hs
		632253 TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21		KPCD_HUMAN (9-518): 2.81e-144: 434: 24.86
+	Mm
		812910 TNR4_MOUSE (52-252): 2.35e-32: 125: 17.91		KPCT_MOUSE (9-508): 6.04e-155: 462: 24.52
+	Hs
		436609 TNR16_HUMAN (40-303): 1.33e-29: 121: 18.46		KAPCB_HUMAN (144-500): 4.26e-143: 419: 29.69