Protein: E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) (Protein tyrosine kinase EIF2AK3) (EC 2.7.10.2)

Gene: E2AK3, EIF2AK3
Organism: Homo sapiens
Interactions: 160
UniProt ID: Q9NZJ5

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001503 - ossification
GO:0001525 - angiogenesis
GO:0002063 - chondrocyte development
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1452310

SCN3B
Sodium channel regulatory subunit beta-3

2

3

High-throughput

0.811

High

535610

BIP
Endoplasmic reticulum chaperone BiP

7

20

Small-scale

0.739

High

1098491

DNJC3
DnaJ homolog subfamily C member 3

1

20

Small-scale

0.724

High

418479

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

5

2

High-throughput

0.716

High

832821

BCL6
B-cell lymphoma 6 protein

1

6

Small-scale

0.691

High

909212

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.691

High

1017500

FOXK1
Forkhead box protein K1

1

14

High-throughput

0.691

High

1029773

FOXK2
Forkhead box protein K2

1

17

High-throughput

0.691

High

1315720

DND1
Dead end protein homolog 1

1

15

High-throughput

0.691

High

1245543

OGFD3
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

3

1

High-throughput

0.667

High

573702

ENPL
Endoplasmin

1

20

Small-scale

0.665

High

1453350

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

16

Small-scale

0.665

High

426345

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

15

Small-scale

0.647

High

1453368

TBL2
Transducin beta-like protein 2

3

14

Small-scale

0.640

High

1430944

GL8D2
Glycosyltransferase 8 domain-containing protein 2

3

0

High-throughput

0.638

High

944934

TMPS3
Transmembrane protease serine 3

2

6

High-throughput

0.628

High

1250235

DLK2
Protein delta homolog 2

2

9

High-throughput

0.628

High

1307248

TF2LY
Homeobox protein TGIF2LY

2

3

High-throughput

0.628

High

1453362

PCDGG
Protocadherin gamma-B4

2

11

High-throughput

0.628

High

1057117

FMOD
Fibromodulin

1

4

High-throughput

0.618

High

126838

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

214467

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

7

Small-scale

0.618

High

461988

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.618

High

466495

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

581335

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

630650

RAB3B
Ras-related protein Rab-3B

1

7

High-throughput

0.618

High

631521

RAB5A
Ras-related protein Rab-5A

1

11

High-throughput

0.618

High

728451

AKT1
RAC-alpha serine/threonine-protein kinase

1

16

Small-scale

0.618

High

820766

CEAM6
Cell adhesion molecule CEACAM6

1

4

High-throughput

0.618

High

901625

RAB7A
Ras-related protein Rab-7a

1

12

High-throughput

0.618

High

902113

RAB9A
Ras-related protein Rab-9A

1

12

High-throughput

0.618

High

910229

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

946733

RHBL3
Rhomboid-related protein 3

1

2

Small-scale

0.618

High

953712

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955685

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

962565

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

1015855

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1125705

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

20

High-throughput

0.618

High

1145139

RAB35
Ras-related protein Rab-35

1

8

High-throughput

0.618

High

1383126

LRC59
Leucine-rich repeat-containing protein 59

1

4

High-throughput

0.618

High

1395970

DNJC1
DnaJ homolog subfamily C member 1

1

20

High-throughput

0.618

High

1431272

DJC25
DnaJ homolog subfamily C member 25

1

14

High-throughput

0.618

High

1453351

BFAR
Bifunctional apoptosis regulator

1

16

High-throughput

0.618

High

1453358

SEC63
Translocation protein SEC63 homolog

1

10

High-throughput

0.618

High

1453361

ALK
ALK tyrosine kinase receptor

1

13

High-throughput

0.618

High

1453365

DJC16
DnaJ homolog subfamily C member 16

1

20

High-throughput

0.618

High

417812

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

3

High-throughput

0.611

High

380370

DRA
HLA class II histocompatibility antigen, DR alpha chain

3

9

High-throughput

0.609

High

568096

HLAE
HLA class I histocompatibility antigen, alpha chain E

3

6

High-throughput

0.609

High

1453357

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

3

7

High-throughput

0.609

High

548136

PSPC
Surfactant protein C

2

0

High-throughput

0.602

High

1244911

NCEH1
Neutral cholesterol ester hydrolase 1

2

0

High-throughput

0.602

High

1453355

P2RX2
P2X purinoceptor 2

2

0

High-throughput

0.602

High

1106181

TUSC3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3

2

2

High-throughput

0.601

High

1417760

EIF2A
Eukaryotic translation initiation factor 2A

2

10

Small-scale

0.584

High

1057589

ACHD
Acetylcholine receptor subunit delta

2

7

High-throughput

0.574

High

1330142

PCD20
Protocadherin-20

2

16

High-throughput

0.574

High

1390896

ASIC4
Acid-sensing ion channel 4

2

6

High-throughput

0.574

High

1453363

PCDA4
Protocadherin alpha-4

2

11

High-throughput

0.574

High

1453364

PCDAC
Protocadherin alpha-12

2

11

High-throughput

0.574

High

1281060

VTCN1
V-set domain-containing T-cell activation inhibitor 1

1

5

Small-scale

0.553

High

380595

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

2

7

High-throughput

0.552

High

380492

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

9

High-throughput

0.536

High

608001

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

7

High-throughput

0.536

High

723269

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

7

High-throughput

0.536

High

813241

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.536

High

963603

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

2

High-throughput

0.536

High

1180975

HFE
Hereditary hemochromatosis protein

1

7

High-throughput

0.536

High

1213721

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

2

High-throughput

0.536

High

1349857

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

High-throughput

0.536

High

1388952

ARSG
Arylsulfatase G

1

2

High-throughput

0.536

High

1447599

ITM2C
Integral membrane protein 2C

1

5

High-throughput

0.536

High

1453352

VAPA
Vesicle-associated membrane protein-associated protein A

1

8

High-throughput

0.536

High

1453359

TSN16
Tetraspanin-16

1

1

High-throughput

0.536

High

1453366

TMED7
Transmembrane emp24 domain-containing protein 7

1

8

High-throughput

0.536

High

1453369

PCDBB
Protocadherin beta-11

1

10

High-throughput

0.536

High

1156710

NF2L2
Nuclear factor erythroid 2-related factor 2

1

11

Small-scale

0.527

High

505204

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.513

High

1137554

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.493

High

838535

GRIA3
Glutamate receptor 3

1

9

High-throughput

0.489

High

1006038

ASIC1
Acid-sensing ion channel 1

1

6

High-throughput

0.489

High

1133845

KI2S3
Killer cell immunoglobulin-like receptor 2DS3

1

1

High-throughput

0.489

High

1206279

NHLC3
NHL repeat-containing protein 3

1

3

High-throughput

0.489

High

1339985

OR6T1
Olfactory receptor 6T1

1

1

High-throughput

0.489

High

1453370

PCDB1
Protocadherin beta-1

1

9

High-throughput

0.489

High

1453371

PCDG4
Protocadherin gamma-A4

1

12

High-throughput

0.489

High

1453372

ST14
Suppressor of tumorigenicity 14 protein

1

7

High-throughput

0.489

High

48827

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

174130

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

10

High-throughput

0.479

High

189884

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

291571

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

294441

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

521038

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

6

High-throughput

0.479

High

586928

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.479

High

604245

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

611389

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

9

High-throughput

0.479

High

617352

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

17

Small-scale

0.479

High

643105

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

675185

TNR6
Tumor necrosis factor receptor superfamily member 6

1

8

Small-scale

0.479

High

699205

CALX
Calnexin

1

6

High-throughput

0.479

High

774673

BASI
Basigin

1

2

High-throughput

0.479

High

837880

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

10

High-throughput

0.479

High

847723

SSRA
Translocon-associated protein subunit alpha

1

2

High-throughput

0.479

High

880722

LMAN1
Protein ERGIC-53

1

5

High-throughput

0.479

High

895118

EMD
Emerin

1

4

High-throughput

0.479

High

951479

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

971203

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

10

High-throughput

0.479

High

1027219

REEP5
Receptor expression-enhancing protein 5

1

2

High-throughput

0.479

High

1058697

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.479

High

1087319

STX4
Syntaxin-4

1

3

High-throughput

0.479

High

1089586

ILF2
Interleukin enhancer-binding factor 2

1

13

Small-scale

0.479

High

1089906

ILF3
Interleukin enhancer-binding factor 3

1

20

Small-scale

0.479

High

1093983

TRAF1
TNF receptor-associated factor 1

1

9

Small-scale

0.479

High

1111732

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

1163434

CAH9
Carbonic anhydrase 9

1

1

High-throughput

0.479

High

1252264

SYNE3
Nesprin-3

1

20

High-throughput

0.479

High

1329914

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

High-throughput

0.479

High

1334041

DHB11
Estradiol 17-beta-dehydrogenase 11

1

4

High-throughput

0.479

High

1352382

RHBL4
Rhomboid-related protein 4

1

3

High-throughput

0.479

High

1370415

CSN5
COP9 signalosome complex subunit 5

1

10

Small-scale

0.479

High

1401719

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

1403814

RMD3
Regulator of microtubule dynamics protein 3

1

2

High-throughput

0.479

High

1404249

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

1412702

ESYT1
Extended synaptotagmin-1

1

4

High-throughput

0.479

High

1431774

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

5

High-throughput

0.479

High

1436343

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.479

High

1448838

TMPS4
Transmembrane protease serine 4

1

5

High-throughput

0.479

High

1453356

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1453360

CLC4E
C-type lectin domain family 4 member E

1

6

High-throughput

0.479

High

1453367

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

1

High-throughput

0.479

High

904167

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

1238840

TECT3
Tectonic-3

1

0

High-throughput

0.458

High

1401246

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1414483

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1421165

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1448031

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1448159

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

1450114

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1452710

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1453353

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1453354

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1346809

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

2

High-throughput

0.445

High

1363468

S39A7
Zinc transporter SLC39A7

1

5

High-throughput

0.445

High

1398003

MF14A
Hippocampus abundant transcript 1 protein

1

3

High-throughput

0.445

High

218873

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.437

High

1286938

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.437

High

1323021

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.437

High

1360951

CLC4D
C-type lectin domain family 4 member D

1

7

High-throughput

0.437

High

1382964

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

1308327

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.426

High

379810

IGHD
Immunoglobulin heavy constant delta

1

2

High-throughput

0.407

High

1185907

TMM95
Sperm-egg fusion protein TMEM95

1

1

High-throughput

0.407

High

1413255

SYT11
Synaptotagmin-11

1

1

High-throughput

0.407

High

219385

B4GA1
Beta-1,4-glucuronyltransferase 1

2

0

High-throughput

0.328

High

377120

GLHA
Glycoprotein hormones alpha chain

1

0

High-throughput

0.279

Low

821692

TPOR
Thrombopoietin receptor

1

0

High-throughput

0.279

Low

1339929

OR2M7
Olfactory receptor 2M7

1

0

High-throughput

0.279

Low

1382079

T106A
Transmembrane protein 106A

1

0

High-throughput

0.279

Low

327088

NXPH3
Neurexophilin-3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025