Protein: E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase)

Gene: E2AK1, EIF2AK1
Organism: Homo sapiens
Interactions: 32
UniProt ID: Q9BQI3

Gene Ontology (top 5):
GO:0002526 - acute inflammatory response
GO:0004694 - eukaryotic translation initiation factor 2alpha kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158500

CDC37
Hsp90 co-chaperone Cdc37

3

11

Small-scale

0.886

High

1025414

CDK6
Cyclin-dependent kinase 6

3

20

High-throughput

0.861

High

461874

HS90A
Heat shock protein HSP 90-alpha

3

20

Small-scale

0.853

High

468743

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.789

High

1106053

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

16

High-throughput

0.789

High

869517

TNFL6
Tumor necrosis factor ligand superfamily member 6

3

1

High-throughput

0.667

High

1121943

DELE1
DAP3-binding cell death enhancer 1

3

6

High-throughput

0.657

High

426324

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

12

Small-scale

0.647

High

537802

HSP7C
Heat shock cognate 71 kDa protein

3

11

Small-scale

0.633

High

1399708

RBM14
RNA-binding protein 14

1

13

High-throughput

0.618

High

732689

ARRB2
Beta-arrestin-2

1

10

High-throughput

0.536

High

1410823

CYBP
Calcyclin-binding protein

1

2

High-throughput

0.536

High

1410828

CHIP
E3 ubiquitin-protein ligase CHIP

1

10

High-throughput

0.536

High

1395280

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.518

High

595577

H15
Histone H1.5

1

4

High-throughput

0.515

High

246905

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

703041

DPOD1
DNA polymerase delta catalytic subunit

1

2

High-throughput

0.479

High

855510

ATRX
Transcriptional regulator ATRX

1

8

High-throughput

0.479

High

935613

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.479

High

1028363

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

1393398

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

2

High-throughput

0.479

High

1410822

EIF2A
Eukaryotic translation initiation factor 2A

1

8

Small-scale

0.479

High

1410825

DDX20
Probable ATP-dependent RNA helicase DDX20

1

11

High-throughput

0.479

High

1410826

XPO7
Exportin-7

1

10

High-throughput

0.479

High

1410827

HSPB8
Heat shock protein beta-8

1

8

Small-scale

0.479

High

1410829

TRRAP
Transformation/transcription domain-associated protein

1

10

High-throughput

0.479

High

892723

DNLI4
DNA ligase 4

1

0

High-throughput

0.460

High

765836

BMI1
Polycomb complex protein BMI-1

1

13

High-throughput

0.445

High

1410824

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

126178

AP3B1
AP-3 complex subunit beta-1

1

7

High-throughput

0.437

High

1394881

EAF1
ELL-associated factor 1

1

0

High-throughput

0.249

Low

1384956

CC127
Coiled-coil domain-containing protein 127

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025