HitPredict

Interactor 1: IF2A (P41374)
Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)
Gene: eIF2alpha

Interactor 2: E2AK3 (Q9NIV1)
Eukaryotic translation initiation factor 2-alpha kinase (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (DmPEK) (PEK) (PERK)
Gene: PEK

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	12605680
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~S1
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 341 Dm			1 1162
+	Mm
		1257507 IF2A_MOUSE (2-310): 1.98e-137: 394: 61.61		E2AK3_MOUSE (34-1119): 0: 936: 31.05
+	Hs
		426345 IF2A_HUMAN (2-310): 8.49e-137: 392: 61.29		E2AK3_HUMAN (44-1123): 0: 912: 30.67
+	Dm
		834817 IF2A_DROME (1-332): 4.67e-142: 407: 100.00		AKT1_DROME (591-1161): 1.69e-134: 424: 13.01
+	Hs
		426194 IF2A_HUMAN (2-310): 8.49e-137: 392: 61.29		KPCA_HUMAN (674-1162): 4.16e-125: 401: 11.27
+	Hs
		426324 IF2A_HUMAN (2-310): 8.49e-137: 392: 61.29		E2AK1_HUMAN (632-1159): 1.18e-89: 304: 27.74
+	Sc
		441035 IF2A_YEAST (5-295): 2.99e-118: 345: 51.03		KAPA_YEAST (780-1162): 4.34e-88: 292: 15.80
+	Hs
		426199 IF2A_HUMAN (2-310): 8.49e-137: 392: 61.29		E2AK2_HUMAN (929-1117): 4.17e-31: 131: 41.58
+	Hs
		426233 IF2A_HUMAN (2-310): 8.49e-137: 392: 61.29		PLK1_HUMAN (928-1117): 1.66e-15: 83.2: 30.57
+	Hs
		426303 IF2A_HUMAN (2-310): 8.49e-137: 392: 61.29		NEK7_HUMAN (961-1112): 1.78e-14: 77.4: 29.30
+	Mm
		1257508 IF2A_MOUSE (2-310): 1.98e-137: 394: 61.61		E2AK1_MOUSE (632-709): 1.03e-10: 67.8: 43.04
+	Sp
		151907 IF2A_SCHPO (3-310): 6.16e-128: 370: 49.36		E2AK1_SCHPO (636-773): 2.47e-15: 83.2: 34.55
+	Sp
		940516 IF2A_SCHPO (3-310): 6.16e-128: 370: 49.36		E2AK2_SCHPO (636-710): 7.64e-13: 74.7: 44.00
+	Sc
		584341 IF2A_YEAST (5-295): 2.99e-118: 345: 51.03		GCN2_YEAST (876-1120): 5.07e-16: 86: 15.89
+	Pf
		91233 IF2A_PLAF7 (4-311): 1.18e-108: 322: 44.01		PK4_PLAF7 (927-1130): 7.69e-18: 92: 31.47
+	Oc
		750577 IF2A_RABIT (2-52): 1.53e-20: 85.2: 78.43		E2AK1_RABIT (632-1157): 2.99e-85: 291: 27.32
+	Zm
		18359 A0A1D6H4I5_MAIZE (10-99): 1.88e-13: 73.6: 21.98		A0A1D6QH07_MAIZE (844-1125): 1.36e-90: 300: 18.82
+	Sc
		441252 RRP5_YEAST (14-110): 1.19e-10: 64.8: 19.59		KAPA_YEAST (780-1162): 4.34e-88: 292: 15.80