HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	30561431, 25681446, 30420664, 32968279, 8943045, 34839354, 37085671, 19815541, 18022363
Identification Methods	affinity chromatography technology, virotrap, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CARD~Death
Common GO terms	GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 455 Hs			1 618
+	Mm
		626867 TNR1A_MOUSE (1-445): 4.25e-127: 377: 64.37		BIRC2_MOUSE (1-618): 0: 657: 82.74
+	Hs
		738663 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		591325 TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		639581 TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Mm
		648960 TNR5_MOUSE (43-326): 7e-52: 178: 20.63		BIRC2_MOUSE (1-618): 0: 657: 82.74
+	Hs
		645799 CD27_HUMAN (42-281): 3.74e-29: 116: 16.87		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Mm
		140023 TNR3_MOUSE (20-331): 1.61e-54: 189: 23.44		BIRC3_MOUSE (21-618): 0: 624: 66.28
+	Mm
		140020 TNR5_MOUSE (43-326): 7e-52: 178: 20.63		BIRC3_MOUSE (21-618): 0: 624: 66.28
+	Hs
		584397 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		738662 TNR3_HUMAN (11-328): 5.78e-63: 211: 24.85		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		591324 TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		436615 TNR16_HUMAN (40-303): 1.33e-29: 121: 18.46		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56