HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: BIG2 (Q9Y6D5)
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)
Gene: ARFGEF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17276987
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 455 Hs			1 1785
+	Hs
		639671 TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64		BIG2_HUMAN (1-1785): 0: 1997: 100.00
+	Hs
		639672 TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64		BIG1_HUMAN (5-1773): 0: 1816: 73.84
+	Hs
		584424 TNR1A_HUMAN (1-455): 1.34e-147: 430: 100.00		MON2_HUMAN (11-228): 1.82e-35: 150: 14.61
+	Hs
		591383 TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86		GBF1_HUMAN (1280-1510): 1.07e-43: 177: 13.31
+	Hs
		639620 TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64		GBF1_HUMAN (1280-1510): 1.07e-43: 177: 13.31
+	Hs
		591362 TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86		MON2_HUMAN (11-228): 1.82e-35: 150: 14.61
+	Hs
		639603 TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64		MON2_HUMAN (11-228): 1.82e-35: 150: 14.61
+	Hs
		639594 TNR5_HUMAN (38-315): 1.92e-46: 163: 19.64		BIG3_HUMAN (15-231): 2.83e-33: 143: 21.88