Protein: NGEF
Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)

Gene: NGEF
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q8N5V2

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0007399 - nervous system development
GO:0016020 - membrane
GO:0030154 - cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

962270

RHOA
Transforming protein RhoA

3

20

Small-scale

0.834

High

835706

KPCI
Protein kinase C iota type

2

14

High-throughput

0.811

High

1051945

KPCD
Protein kinase C delta type

2

12

High-throughput

0.811

High

473443

HCK
Tyrosine-protein kinase HCK

2

19

High-throughput

0.767

High

258606

SH21A
SH2 domain-containing protein 1A

2

20

High-throughput

0.743

High

1328555

FEM1A
Protein fem-1 homolog A

1

6

High-throughput

0.691

High

374762

RASH
GTPase HRas

1

11

High-throughput

0.665

High

1328545

DEP1B
DEP domain-containing protein 1B

2

7

High-throughput

0.659

High

837241

ACTY
Beta-centractin

2

7

High-throughput

0.628

High

1328566

ARP10
Actin-related protein 10

2

6

High-throughput

0.628

High

47912

S12A8
Solute carrier family 12 member 8

2

1

High-throughput

0.621

High

932100

EPHA4
Ephrin type-A receptor 4

1

20

Small-scale

0.618

High

955376

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.618

High

988526

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.618

High

246043

KIF1B
Kinesin-like protein KIF1B

1

10

High-throughput

0.594

High

650295

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.594

High

978162

RHOB
Rho-related GTP-binding protein RhoB

1

20

Small-scale

0.590

High

158257

COPE
Coatomer subunit epsilon

2

3

High-throughput

0.571

High

1005696

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

2

3

High-throughput

0.571

High

1328543

NUP35
Nucleoporin NUP35

2

2

High-throughput

0.571

High

1254641

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

187755

EIF3D
Eukaryotic translation initiation factor 3 subunit D

2

0

High-throughput

0.547

High

784660

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

3

High-throughput

0.541

High

1328574

HCFC2
Host cell factor 2

1

6

High-throughput

0.536

High

415721

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.515

High

442402

GELS
Gelsolin

1

5

High-throughput

0.515

High

1249939

LRRN1
Leucine-rich repeat neuronal protein 1

1

0

High-throughput

0.513

High

1328544

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.513

High

228316

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

1

High-throughput

0.508

High

161060

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

7

Small-scale

0.501

High

1328547

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

High-throughput

0.501

High

1328551

SMO
Protein smoothened

1

1

High-throughput

0.494

High

1328557

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.494

High

705465

GRN
Progranulin

1

0

High-throughput

0.493

High

843766

HD
Huntingtin

1

0

High-throughput

0.493

High

225313

HTSF1
17S U2 SnRNP complex component HTATSF1

1

7

High-throughput

0.489

High

1328554

GORS1
Golgi reassembly-stacking protein 1

1

1

High-throughput

0.489

High

1328559

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

High-throughput

0.486

High

210993

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

254185

CTND1
Catenin delta-1

1

14

High-throughput

0.479

High

408102

TBB4A
Tubulin beta-4A chain

1

4

High-throughput

0.479

High

451216

NFL
Neurofilament light polypeptide

1

19

High-throughput

0.479

High

656188

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

9

High-throughput

0.479

High

786171

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

897900

CDK9
Cyclin-dependent kinase 9

1

7

High-throughput

0.479

High

910994

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.479

High

912635

GDIR2
Rho GDP-dissociation inhibitor 2

1

1

High-throughput

0.479

High

921953

COPA
Coatomer subunit alpha

1

4

High-throughput

0.479

High

934114

XPO2
Exportin-2

1

8

High-throughput

0.479

High

1130105

SMC1A
Structural maintenance of chromosomes protein 1A

1

6

High-throughput

0.479

High

1291065

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

9

High-throughput

0.479

High

1294087

DDX42
ATP-dependent RNA helicase DDX42

1

5

High-throughput

0.479

High

1328542

NUP43
Nucleoporin Nup43

1

11

High-throughput

0.479

High

1328558

XRN2
5'-3' exoribonuclease 2

1

2

High-throughput

0.479

High

1328564

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

1328568

TPX2
Targeting protein for Xklp2

1

5

High-throughput

0.479

High

1328571

NOP58
Nucleolar protein 58

1

3

High-throughput

0.479

High

1328576

COPG1
Coatomer subunit gamma-1

1

10

High-throughput

0.479

High

1328548

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.439

High

750449

CSTF2
Cleavage stimulation factor subunit 2

1

7

High-throughput

0.437

High

895601

SERPH
Serpin H1

1

6

High-throughput

0.437

High

1048596

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

3

High-throughput

0.437

High

1119969

CIRBP
Cold-inducible RNA-binding protein

1

10

High-throughput

0.437

High

1203570

ZN326
DBIRD complex subunit ZNF326

1

3

High-throughput

0.437

High

1217159

RIF1
Telomere-associated protein RIF1

1

10

High-throughput

0.437

High

1328546

PSPC1
Paraspeckle component 1

1

9

High-throughput

0.437

High

1328550

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.437

High

1328556

SF3B5
Splicing factor 3B subunit 5

1

3

High-throughput

0.437

High

1328565

MIC19
MICOS complex subunit MIC19

1

4

High-throughput

0.437

High

1328567

STML2
Stomatin-like protein 2, mitochondrial

1

2

High-throughput

0.437

High

1328569

UTP16
U3 small nucleolar RNA-associated protein NOL7

1

3

High-throughput

0.437

High

1328572

SF3B6
Splicing factor 3B subunit 6

1

13

High-throughput

0.437

High

1328563

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

0

High-throughput

0.328

High

1162425

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.298

High

1328549

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

301562

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1328573

RNF11
RING finger protein 11

1

0

High-throughput

0.268

Low

1328575

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1328552

CG025
UPF0415 protein C7orf25

1

0

High-throughput

0.265

Low

1328553

F118B
Protein FAM118B

1

0

High-throughput

0.265

Low

1328560

CH033
UPF0488 protein C8orf33

1

0

High-throughput

0.265

Low

1328562

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.265

Low

359690

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.249

Low

720509

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

1032017

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.249

Low

1220521

MIC13
MICOS complex subunit MIC13

1

0

High-throughput

0.249

Low

1328561

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

1328570

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025