HitPredict

Interactor 1: ERCC3 (P19447)
General transcription and DNA repair factor IIH helicase/translocase subunit XPB (TFIIH subunit XPB) (EC 5.6.2.4) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA 3'-5' helicase/translocase XPB) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)
Gene: ERCC3

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20195357
Identification Methods	display technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 782 Hs			1 467
+	Mm
		824614 ERCC3_MOUSE (1-782): 0: 712: 95.79		SMAD9_MOUSE (1-467): 0: 575: 58.40
+	Mm
		824610 ERCC3_MOUSE (1-782): 0: 712: 95.79		SMAD5_MOUSE (1-467): 0: 568: 55.25
+	Mm
		824609 ERCC3_MOUSE (1-782): 0: 712: 95.79		SMAD1_MOUSE (1-467): 0: 566: 55.42
+	Mm
		1143947 Q8BTS0_MOUSE (198-712): 3.77e-107: 342: 12.87		SMAD2_MOUSE (1-467): 0: 675: 99.57
+	Hs
		181701 DDX3Y_HUMAN (201-677): 7.95e-102: 329: 10.85		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		571401 DDX5_HUMAN (198-775): 3.03e-108: 345: 12.56		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Mm
		1207259 Q8BTS0_MOUSE (198-712): 3.77e-107: 342: 12.87		SMAD3_MOUSE (1-467): 0: 617: 83.94
+	Hs
		133977 DDX3X_HUMAN (204-677): 1.56e-104: 337: 11.22		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		181693 DDX3Y_HUMAN (201-677): 7.95e-102: 329: 10.85		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		571568 DDX5_HUMAN (198-775): 3.03e-108: 345: 12.56		SMAD5_HUMAN (1-467): 0: 570: 55.45
+	Hs
		571470 DDX5_HUMAN (198-775): 3.03e-108: 345: 12.56		SMAD1_HUMAN (1-467): 0: 565: 55.53
+	Mm
		936615 Q8BTS0_MOUSE (198-712): 3.77e-107: 342: 12.87		SMAD1_MOUSE (1-467): 0: 566: 55.42
+	Mm
		956548 Q8BTS0_MOUSE (198-712): 3.77e-107: 342: 12.87		SMAD4_MOUSE (11-456): 1.37e-150: 441: 31.46
+	Mm
		192488 Q8BTS0_MOUSE (198-712): 3.77e-107: 342: 12.87		SMAD7_MOUSE (13-443): 5.17e-112: 338: 25.00