HitPredict

Interactor 1: PCNA (P15873)
Proliferating cell nuclear antigen (PCNA)
Gene: POL30

Interactor 2: MSH6 (Q03834)
DNA mismatch repair protein MSH6 (MutS protein homolog 6) (Postmeiotic segregation protein 3)
Gene: MSH6

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	20967232, 12239216, 23869605, 11005803, 26903512, 22308326, 12435741, 17531814, 29281621, 24981171, 23267104
Identification Methods	solid phase assay, surface plasmon resonance, affinity chromatography technology, two hybrid, pull down, unspecified method, miniaturized immunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000710 - meiotic mismatch repair GO:0005634 - nucleus GO:0006298 - mismatch repair
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 258 Sc			1 1242
+	Hs
		550937 PCNA_HUMAN (1-258): 2.38e-109: 317: 35.52		MSH6_HUMAN (60-1198): 0: 1045: 28.78
+	Sp
		267780 PCNA_SCHPO (1-258): 9.87e-103: 300: 44.57		MSH6_SCHPO (74-1202): 0: 1056: 39.74
+	Hs
		253195 RAD1_HUMAN (2-258): 1.1e-64: 204: 15.87		MSH6_HUMAN (60-1198): 0: 1045: 28.78
+	Hs
		550834 PCNA_HUMAN (1-258): 2.38e-109: 317: 35.52		MSH3_HUMAN (164-1176): 0: 884: 23.37
+	Hs
		550910 PCNA_HUMAN (1-258): 2.38e-109: 317: 35.52		MSH2_HUMAN (298-1193): 0: 838: 22.07
+	Hs
		253186 RAD1_HUMAN (2-258): 1.1e-64: 204: 15.87		MSH3_HUMAN (164-1176): 0: 884: 23.37
+	Hs
		253193 RAD1_HUMAN (2-258): 1.1e-64: 204: 15.87		MSH2_HUMAN (298-1193): 0: 838: 22.07
+	Sc
		586434 PCNA_YEAST (1-258): 5.34e-95: 281: 100.00		MSH2_YEAST (314-1209): 0: 713: 20.59
+	Sc
		586430 PCNA_YEAST (1-258): 5.34e-95: 281: 100.00		MSH3_YEAST (310-1210): 0: 668: 22.79