Protein: MSH2
DNA mismatch repair protein MSH2 (MutS protein homolog 2)

Gene: MSH2
Organism: Saccharomyces cerevisiae S288C
Interactions: 79
UniProt ID: P25847

Gene Ontology (top 5):
GO:0000228 - nuclear chromosome
GO:0000400 - four-way junction DNA binding
GO:0000406 - double-strand/single-strand DNA junction binding
GO:0000710 - meiotic mismatch repair
GO:0000735 - removal of nonhomologous ends

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

682938

MSH6
DNA mismatch repair protein MSH6

33

13

Small-scale

0.993

High

672000

MSH3
DNA mismatch repair protein MSH3

10

12

Small-scale

0.975

High

682916

MLH1
DNA mismatch repair protein MLH1

7

20

Small-scale

0.963

High

571273

PMS1
DNA mismatch repair protein PMS1

7

20

Small-scale

0.963

High

578948

HSC82
ATP-dependent molecular chaperone HSC82

2

5

High-throughput

0.759

High

682919

EXO1
Exodeoxyribonuclease 1

7

6

Small-scale

0.748

High

586434

PCNA
Proliferating cell nuclear antigen

7

9

Small-scale

0.741

High

682918

SAW1
Single-strand annealing weakened protein 1

3

1

Small-scale

0.680

High

647709

RFA1
Replication factor A protein 1

3

5

Small-scale

0.662

High

449281

RAD10
DNA repair protein RAD10

2

2

Small-scale

0.651

High

682945

MLH2
DNA mismatch repair protein MLH2

1

20

Small-scale

0.647

High

682943

HDA2
HDA1 complex subunit 2

3

0

High-throughput

0.637

High

448364

RAD1
DNA repair protein RAD1

2

2

Small-scale

0.605

High

682931

PROA
Gamma-glutamyl phosphate reductase

2

0

High-throughput

0.595

High

682942

HDA3
HDA1 complex subunit 3

2

0

High-throughput

0.595

High

682925

RSC8
Chromatin structure-remodeling complex protein RSC8

2

1

High-throughput

0.588

High

682899

RAD14
DNA repair protein RAD14

1

2

Small-scale

0.573

High

682936

LGE1
Transcriptional regulatory protein LGE1

2

2

High-throughput

0.571

High

682939

RUVB1
RuvB-like protein 1

2

1

High-throughput

0.571

High

682930

HDA1
Histone deacetylase HDA1

2

3

High-throughput

0.567

High

518225

IF4A
ATP-dependent RNA helicase eIF4A

2

0

High-throughput

0.563

High

682915

OLA1
Obg-like ATPase 1

2

0

High-throughput

0.563

High

454651

RAD2
DNA repair protein RAD2

1

6

Small-scale

0.552

High

682948

SLX4
Structure-specific endonuclease subunit SLX4

1

1

Small-scale

0.552

High

526057

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

544001

SSB1
Ribosome-associated molecular chaperone SSB1

2

13

High-throughput

0.552

High

682933

RAD25
General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2

1

0

Small-scale

0.549

High

682941

SWR1
Helicase SWR1

1

2

High-throughput

0.541

High

682937

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

1

0

High-throughput

0.518

High

644656

MAG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.513

High

682911

SGS1
ATP-dependent helicase SGS1

1

7

Small-scale

0.501

High

682898

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.493

High

682920

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.493

High

682922

MMM1
Maintenance of mitochondrial morphology protein 1

1

2

Small-scale

0.489

High

449319

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

0

Small-scale

0.486

High

682901

FUN30
ATP-dependent helicase FUN30

1

8

Small-scale

0.481

High

682909

RAD5
DNA repair protein RAD5

1

8

Small-scale

0.481

High

682924

GZF3
Protein GZF3

1

2

High-throughput

0.481

High

682934

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

2

High-throughput

0.481

High

594225

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

682900

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

682902

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

682907

MG101
Mitochondrial genome maintenance protein MGM101

1

1

Small-scale

0.479

High

682908

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

682921

MPH1
ATP-dependent DNA helicase MPH1

1

3

High-throughput

0.479

High

682929

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

Small-scale

0.479

High

682932

H3
Histone H3

1

10

High-throughput

0.479

High

682947

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

682949

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.479

High

682951

CMR1
DNA damage-binding protein CMR1

1

5

High-throughput

0.479

High

649206

SAN1
Protein SAN1

1

0

Small-scale

0.460

High

682897

DPB3
DNA polymerase epsilon subunit C

1

0

Small-scale

0.460

High

682910

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

682928

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

682946

SGO1
Shugoshin

1

0

High-throughput

0.458

High

682935

UBC7
Ubiquitin-conjugating enzyme E2 7

1

4

High-throughput

0.457

High

364953

KPYK1
Pyruvate kinase 1

1

3

High-throughput

0.445

High

419625

H2A2
Histone H2A.2

1

4

High-throughput

0.445

High

523216

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.445

High

592053

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.445

High

668358

ROX1
Repressor ROX1

1

2

High-throughput

0.445

High

675757

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

682904

ASF1
Histone chaperone ASF1

1

1

High-throughput

0.445

High

682906

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.445

High

682913

SET3
SET domain-containing protein 3

1

1

High-throughput

0.445

High

682940

YHP1
Homeobox protein YHP1

1

1

High-throughput

0.445

High

682950

CAF1A
Chromatin assembly factor 1 subunit A

1

5

High-throughput

0.445

High

682903

RIM1
Single-stranded DNA-binding protein RIM1, mitochondrial

1

2

High-throughput

0.437

High

682912

UTP20
U3 small nucleolar RNA-associated protein 20

1

1

High-throughput

0.437

High

486058

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

682905

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

1

0

High-throughput

0.426

High

394292

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

682923

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.407

High

682927

TPC1
Mitochondrial thiamine pyrophosphate carrier 1

1

0

High-throughput

0.282

High

682914

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

682917

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

682944

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

506503

YL016
Putative truncated guanine nucleotide exchange factor SDC25

1

0

High-throughput

0.238

Low

682926

RSSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025