HitPredict

Interactor 1: NCF2 (P19878)
Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox)
Gene: NCF2

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	25301945, 9624165, 9642115, 11090627, 25416956
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, isothermal titration calorimetry, mammalian protein protein interaction trap
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Ras~TPR_8
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0043020 - NADPH oxidase complex GO:0045730 - respiratory burst
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 192
+	Hs
		545204 NCF2_HUMAN (1-526): 9.93e-130: 389: 100.00		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		587799 NCF2_HUMAN (1-526): 9.93e-130: 389: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		925403 NOXA1_HUMAN (2-524): 5.3e-84: 270: 27.48		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		925240 MYO1E_HUMAN (19-514): 1.56e-57: 208: 13.95		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		564501 MYO1E_HUMAN (19-514): 1.56e-57: 208: 13.95		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545347 MYO1E_HUMAN (19-514): 1.56e-57: 208: 13.95		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		1021704 MYO1E_HUMAN (19-514): 1.56e-57: 208: 13.95		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		892342 MYO1E_HUMAN (19-514): 1.56e-57: 208: 13.95		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		950955 MYO1E_HUMAN (19-514): 1.56e-57: 208: 13.95		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		893949 MYO1E_HUMAN (19-514): 1.56e-57: 208: 13.95		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900425 MYO1E_HUMAN (19-514): 1.56e-57: 208: 13.95		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436279 MYO1E_HUMAN (19-514): 1.56e-57: 208: 13.95		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		925192 RHG04_HUMAN (2-520): 2.7e-42: 163: 12.48		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		49630 RHG10_HUMAN (22-514): 1.13e-34: 140: 11.88		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		49631 RHG10_HUMAN (22-514): 1.13e-34: 140: 11.88		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		925459 SH3R2_HUMAN (246-511): 2.57e-18: 90.3: 20.00		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		925396 SH3R1_HUMAN (309-512): 2.24e-15: 81.4: 16.98		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		894047 ITSN1_HUMAN (48-526): 1.75e-18: 91.4: 11.92		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		924448 GRB2_HUMAN (461-515): 5.96e-12: 67.2: 32.14		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		893878 GRB2_HUMAN (461-515): 5.96e-12: 67.2: 32.14		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31