Protein: EPIPL
Epiplakin (450 kDa epidermal antigen)

Gene: EPIPL, EPPK1
Organism: Homo sapiens
Interactions: 198
UniProt ID: P58107

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005198 - structural molecule activity
GO:0005737 - cytoplasm
GO:0005856 - cytoskeleton
GO:0005923 - bicellular tight junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

474585

VIME
Vimentin

5

20

High-throughput

0.718

High

945842

CDK15
Cyclin-dependent kinase 15

2

9

High-throughput

0.628

High

945882

FCF1
rRNA-processing protein FCF1 homolog

2

2

High-throughput

0.628

High

436833

K1C18
Keratin, type I cytoskeletal 18

2

20

High-throughput

0.611

High

945790

CUL3
Cullin-3

2

14

High-throughput

0.611

High

945877

DD19B
ATP-dependent RNA helicase DDX19B

2

7

High-throughput

0.611

High

945781

FGL1
Fibrinogen-like protein 1

3

1

High-throughput

0.609

High

945852

RBM24
RNA-binding protein 24

3

6

High-throughput

0.609

High

563500

CFTR
Cystic fibrosis transmembrane conductance regulator

2

10

High-throughput

0.601

High

690866

1433T
14-3-3 protein theta

2

20

High-throughput

0.601

High

241237

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

945870

TB22B
TBC1 domain family member 22B

2

7

High-throughput

0.574

High

934351

TERA
Transitional endoplasmic reticulum ATPase

2

5

High-throughput

0.571

High

945824

POC5
Centrosomal protein POC5

2

5

Small-scale

0.571

High

600542

ZSC20
Zinc finger and SCAN domain-containing protein 20

2

3

High-throughput

0.558

High

227208

KRT86
Keratin, type II cuticular Hb6

1

20

High-throughput

0.536

High

254912

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.536

High

325310

OR2A4
Olfactory receptor 2A4

1

3

High-throughput

0.536

High

341753

K2C75
Keratin, type II cytoskeletal 75

1

19

High-throughput

0.536

High

385076

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.536

High

395779

ESR1
Estrogen receptor

1

19

High-throughput

0.536

High

413502

P53
Cellular tumor antigen p53

1

7

High-throughput

0.536

High

451357

NFM
Neurofilament medium polypeptide

1

20

High-throughput

0.536

High

475750

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.536

High

551544

K2C3
Keratin, type II cytoskeletal 3

1

20

High-throughput

0.536

High

602769

AATC
Aspartate aminotransferase, cytoplasmic

1

5

High-throughput

0.536

High

733319

CCR1
C-C chemokine receptor type 1

1

6

High-throughput

0.536

High

843433

HD
Huntingtin

1

4

High-throughput

0.536

High

876301

PTSS1
Phosphatidylserine synthase 1

1

4

High-throughput

0.536

High

945770

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.536

High

945773

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.536

High

945779

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

945789

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

945792

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.536

High

945793

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.536

High

945796

K2C72
Keratin, type II cytoskeletal 72

1

20

High-throughput

0.536

High

945799

K1H1
Keratin, type I cuticular Ha1

1

20

High-throughput

0.536

High

945802

LRC10
Leucine-rich repeat-containing protein 10

1

8

High-throughput

0.536

High

945803

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

11

High-throughput

0.536

High

945812

K1C27
Keratin, type I cytoskeletal 27

1

20

High-throughput

0.536

High

945815

K2C73
Keratin, type II cytoskeletal 73

1

20

High-throughput

0.536

High

945820

K2C78
Keratin, type II cytoskeletal 78

1

20

High-throughput

0.536

High

945833

PIGT
GPI-anchor transamidase component PIGT

1

2

High-throughput

0.536

High

945834

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

3

High-throughput

0.536

High

945839

CERS2
Ceramide synthase 2

1

3

High-throughput

0.536

High

945845

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.536

High

945856

K1C23
Keratin, type I cytoskeletal 23

1

20

High-throughput

0.536

High

945869

KRT82
Keratin, type II cuticular Hb2

1

20

High-throughput

0.536

High

945871

KLH11
Kelch-like protein 11

1

3

High-throughput

0.536

High

945863

WDR76
WD repeat-containing protein 76

2

20

High-throughput

0.533

High

945866

ANLN
Anillin

2

9

High-throughput

0.533

High

648120

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.515

High

830440

CCNF
Cyclin-F

1

5

High-throughput

0.515

High

945766

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.515

High

945800

T22D1
TSC22 domain family protein 1

1

4

High-throughput

0.515

High

945846

PHB2
Prohibitin-2

1

1

High-throughput

0.515

High

945875

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

2

High-throughput

0.515

High

945876

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.515

High

945884

TRAF6
TNF receptor-associated factor 6

1

19

High-throughput

0.515

High

213401

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

2

High-throughput

0.504

High

945763

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

945885

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

8

Small-scale

0.501

High

352378

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.493

High

945880

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.493

High

896684

ASCL1
Achaete-scute homolog 1

1

7

High-throughput

0.489

High

943030

STX17
Syntaxin-17

1

4

High-throughput

0.489

High

945777

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

1

High-throughput

0.489

High

945801

CR021
UPF0711 protein C18orf21

1

3

High-throughput

0.489

High

945814

ZC3C1
Zinc finger C3HC-type protein 1

1

3

High-throughput

0.489

High

945816

CERS3
Ceramide synthase 3

1

3

High-throughput

0.489

High

945836

SARAF
Store-operated calcium entry-associated regulatory factor

1

2

High-throughput

0.489

High

945841

F227B
Protein FAM227B

1

2

High-throughput

0.489

High

945849

WDR83
WD repeat domain-containing protein 83

1

13

High-throughput

0.489

High

157151

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.479

High

192999

CFLAR
CASP8 and FADD-like apoptosis regulator

1

1

High-throughput

0.479

High

222867

PRC1
Protein regulator of cytokinesis 1

1

15

High-throughput

0.479

High

247276

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

7

High-throughput

0.479

High

272023

OBSL1
Obscurin-like protein 1

1

19

High-throughput

0.479

High

277338

TP4A3
Protein tyrosine phosphatase type IVA 3

1

11

High-throughput

0.479

High

293449

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

297532

PIAS1
E3 SUMO-protein ligase PIAS1

1

5

High-throughput

0.479

High

314938

TRPM2
Transient receptor potential cation channel subfamily M member 2

1

2

High-throughput

0.479

High

323259

TRI37
E3 ubiquitin-protein ligase TRIM37

1

18

High-throughput

0.479

High

330802

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

425407

ISG15
Ubiquitin-like protein ISG15

1

12

High-throughput

0.479

High

437133

K2C8
Keratin, type II cytoskeletal 8

1

20

High-throughput

0.479

High

477222

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

18

High-throughput

0.479

High

485018

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

7

High-throughput

0.479

High

507743

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

Small-scale

0.479

High

519887

ANDR
Androgen receptor

1

18

High-throughput

0.479

High

555364

SKI
Ski oncogene

1

3

Small-scale

0.479

High

560345

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

565842

EF2
Elongation factor 2

1

6

High-throughput

0.479

High

622563

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

High-throughput

0.479

High

630235

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

3

High-throughput

0.479

High

634381

LMNB1
Lamin-B1

1

20

High-throughput

0.479

High

808002

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

High-throughput

0.479

High

834738

M3K8
Mitogen-activated protein kinase kinase kinase 8

1

11

High-throughput

0.479

High

846201

MATR3
Matrin-3

1

2

High-throughput

0.479

High

861088

MAP1B
Microtubule-associated protein 1B

1

14

High-throughput

0.479

High

887880

MCM2
DNA replication licensing factor MCM2

1

9

High-throughput

0.479

High

945761

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

12

High-throughput

0.479

High

945762

RHOA
Transforming protein RhoA

1

13

High-throughput

0.479

High

945767

RHOB
Rho-related GTP-binding protein RhoB

1

15

High-throughput

0.479

High

945768

H4
Histone H4

1

5

High-throughput

0.479

High

945769

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

12

High-throughput

0.479

High

945771

KCNJ2
Inward rectifier potassium channel 2

1

3

Small-scale

0.479

High

945774

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

20

High-throughput

0.479

High

945776

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

18

High-throughput

0.479

High

945778

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.479

High

945783

MERTK
Tyrosine-protein kinase Mer

1

14

High-throughput

0.479

High

945785

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

9

High-throughput

0.479

High

945786

TIF1B
Transcription intermediary factor 1-beta

1

12

High-throughput

0.479

High

945787

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

945791

CUL4A
Cullin-4A

1

14

High-throughput

0.479

High

945794

NBR1
Next to BRCA1 gene 1 protein

1

3

High-throughput

0.479

High

945795

CUL7
Cullin-7

1

12

High-throughput

0.479

High

945798

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

945804

FTM
Protein fantom

1

20

High-throughput

0.479

High

945805

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

945806

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.479

High

945809

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

2

Small-scale

0.479

High

945810

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

945813

ZN598
E3 ubiquitin-protein ligase ZNF598

1

8

High-throughput

0.479

High

945823

CE120
Centrosomal protein of 120 kDa

1

20

High-throughput

0.479

High

945827

NUDC2
NudC domain-containing protein 2

1

4

High-throughput

0.479

High

945829

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

High-throughput

0.479

High

945830

AKAP1
A-kinase anchor protein 1, mitochondrial

1

2

High-throughput

0.479

High

945832

FGF11
Fibroblast growth factor 11

1

2

High-throughput

0.479

High

945837

GCP3
Gamma-tubulin complex component 3

1

1

High-throughput

0.479

High

945847

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

10

High-throughput

0.479

High

945850

INP5K
Inositol polyphosphate 5-phosphatase K

1

2

High-throughput

0.479

High

945853

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

12

High-throughput

0.479

High

945854

RNF17
RING finger protein 17

1

2

High-throughput

0.479

High

945858

CCDC8
Coiled-coil domain-containing protein 8

1

6

High-throughput

0.479

High

945859

CHM4B
Charged multivesicular body protein 4b

1

6

High-throughput

0.479

High

945860

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

945862

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

945864

RHOF
Rho-related GTP-binding protein RhoF

1

17

High-throughput

0.479

High

945865

E41LA
Band 4.1-like protein 4A

1

11

High-throughput

0.479

High

945867

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

945872

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

945873

WRP73
WD repeat-containing protein WRAP73

1

15

High-throughput

0.479

High

945874

HDAC6
Protein deacetylase HDAC6

1

10

High-throughput

0.479

High

945879

SRRM2
Serine/arginine repetitive matrix protein 2

1

13

High-throughput

0.479

High

945886

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.479

High

945828

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.470

High

161663

TRDMT
tRNA

1

0

High-throughput

0.458

High

291279

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

405262

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

941889

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

945817

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.458

High

945818

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

Small-scale

0.458

High

945861

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

0

High-throughput

0.458

High

618135

K2C4
Keratin, type II cytoskeletal 4

1

20

High-throughput

0.445

High

945784

STK4
Serine/threonine-protein kinase 4

1

20

High-throughput

0.445

High

945788

SQSTM
Sequestosome-1

1

14

High-throughput

0.445

High

945807

OLFM4
Olfactomedin-4

1

2

High-throughput

0.445

High

945878

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.445

High

138987

BCL9
B-cell CLL/lymphoma 9 protein

1

7

Small-scale

0.437

High

165454

RGRF2
Ras-specific guanine nucleotide-releasing factor 2

1

14

High-throughput

0.437

High

188849

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.437

High

353161

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.437

High

371595

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.437

High

418909

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.437

High

720171

UFO
Tyrosine-protein kinase receptor UFO

1

15

High-throughput

0.437

High

754777

H2B1B
Histone H2B type 1-B

1

11

High-throughput

0.437

High

786997

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

945764

WDR5
WD repeat-containing protein 5

1

15

High-throughput

0.437

High

945765

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.437

High

945775

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

945780

CTSL2
CTD small phosphatase-like protein 2

1

1

Small-scale

0.437

High

945797

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.437

High

945811

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.437

High

945819

CNTRB
Centrobin

1

20

High-throughput

0.437

High

945822

NKAI3
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3

1

5

High-throughput

0.437

High

945825

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.437

High

945826

DEP1B
DEP domain-containing protein 1B

1

3

High-throughput

0.437

High

945831

ESR2
Estrogen receptor beta

1

18

High-throughput

0.437

High

945838

SPDLY
Protein Spindly

1

20

High-throughput

0.437

High

945840

AURKB
Aurora kinase B

1

14

High-throughput

0.437

High

945843

CIC
Protein capicua homolog

1

20

High-throughput

0.437

High

945851

CP250
Centrosome-associated protein CEP250

1

20

High-throughput

0.437

High

945855

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.437

High

945881

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

945883

TRRAP
Transformation/transcription domain-associated protein

1

5

High-throughput

0.437

High

844746

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

945848

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.426

High

47443

A0A6Q8PFP9
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein

1

5

High-throughput

0.407

High

765296

BMI1
Polycomb complex protein BMI-1

1

17

High-throughput

0.407

High

945772

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.407

High

945808

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

3

High-throughput

0.407

High

945857

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

12

High-throughput

0.407

High

945868

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.407

High

945821

CCD82
Coiled-coil domain-containing protein 82

1

0

High-throughput

0.279

Low

945835

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.249

Low

945782

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.232

Low

945844

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025