HitPredict

Interactor 1: TRA2A (Q13595)
Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A)
Gene: TRA2A

Interactor 2: DYRK2 (Q92630)
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)
Gene: DYRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 282 Hs			1 601
+	Hs
		625415 TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		516362 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		1040325 TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Dm
		1213421 MSIR6_DROME (2-253): 3.96e-47: 162: 18.43		AKT1_DROME (6-510): 1.51e-116: 361: 16.32
+	Hs
		1031320 PABP4_HUMAN (1-267): 6.75e-38: 142: 14.13		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		516508 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		925032 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		201668 MSI1H_HUMAN (100-255): 8.46e-26: 106: 22.22		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Mm
		554885 TIA1_MOUSE (114-207): 2.24e-18: 86: 21.28		KPCE_MOUSE (55-510): 2.32e-124: 385: 16.70
+	Mm
		554897 TIAR_MOUSE (113-253): 1.32e-16: 81: 18.52		KPCE_MOUSE (55-510): 2.32e-124: 385: 16.70
+	At
		621700 RB45A_ARATH (108-275): 1.01e-12: 69.4: 15.64		CDKA1_ARATH (219-538): 8.93e-128: 379: 24.77
+	Hs
		1043781 CIRBP_HUMAN (121-193): 2.19e-10: 60.1: 58.90		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Sc
		376610 PABP_YEAST (12-109): 4.14e-09: 59: 9.18		YAK1_YEAST (117-573): 7.71e-111: 352: 32.27
+	Hs
		833731 TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00		CLK1_HUMAN (204-535): 3.1e-62: 215: 35.80
+	Hs
		833877 TRA2A_HUMAN (1-253): 2.19e-47: 161: 100.00		CLK2_HUMAN (204-543): 6.41e-57: 201: 31.56
+	Hs
		516416 PABP1_HUMAN (1-267): 1.05e-37: 142: 13.77		CLK2_HUMAN (204-543): 6.41e-57: 201: 31.56
+	Hs
		833706 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		CLK1_HUMAN (204-535): 3.1e-62: 215: 35.80
+	Hs
		833857 TRA2B_HUMAN (1-279): 2.66e-34: 127: 52.30		CLK2_HUMAN (204-543): 6.41e-57: 201: 31.56
+	Zm
		16139 A0A1D6GKL8_MAIZE (122-197): 2.22e-27: 105: 40.79		A0A1D6JDK3_MAIZE (161-535): 2.37e-55: 203: 33.63
+	Zm
		5286 A0A1D6DYK5_MAIZE (116-275): 4.93e-12: 67.5: 16.95		A0A1D6M674_MAIZE (221-427): 4.66e-12: 71.2: 28.84