HitPredict

Interactor 1: TRYB2 (P20231)
Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II)
Gene: TPSB2

Interactor 2: TRYB2 (P20231)
Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II)
Gene: TPSB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.851

Property	Details
Experiments	28514442, 11325588, 10500112, 9521329
Identification Methods	affinity chromatography technology, x-ray crystallography
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Trypsin~Trypsin
Common GO terms	GO:0004252 - serine-type endopeptidase activity GO:0005615 - extracellular space GO:0006508 - proteolysis GO:0008236 - serine-type peptidase activity GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 275 Hs			1 275
+	Hs
		1076585 TRYB1_HUMAN (13-275): 2.06e-123: 354: 98.86		TRYB1_HUMAN (13-275): 2.06e-123: 354: 98.86
+	Hs
		371453 FA11_HUMAN (15-273): 1.36e-98: 302: 36.50		FA11_HUMAN (15-273): 1.36e-98: 302: 36.50
+	Hs
		428658 TRY1_HUMAN (1-274): 8.64e-103: 301: 33.33		TRY2_HUMAN (30-274): 4.3e-99: 291: 34.40
+	Hs
		428717 TRY2_HUMAN (30-274): 4.3e-99: 291: 34.40		TRY3_HUMAN (26-274): 5.64e-97: 288: 34.65
+	Hs
		568136 CTRB1_HUMAN (1-274): 3.39e-99: 292: 34.64		CTRB2_HUMAN (1-274): 5.44e-97: 287: 33.57
+	Hs
		177736 TMPS2_HUMAN (10-273): 7.84e-95: 289: 33.21		TMPS2_HUMAN (10-273): 7.84e-95: 289: 33.21
+	Hs
		1198079 TM11B_HUMAN (7-269): 2.01e-95: 288: 32.33		TM11B_HUMAN (7-269): 2.01e-95: 288: 32.33
+	Hs
		1345069 TMPS4_HUMAN (19-274): 3.52e-93: 283: 34.50		TMPS4_HUMAN (19-274): 3.52e-93: 283: 34.50
+	Hs
		437547 CEL2A_HUMAN (1-274): 8.17e-98: 289: 35.21		CEL2B_HUMAN (1-274): 3.85e-90: 269: 35.56