HitPredict

Interactor 1: RAB4A (P20338)
Ras-related protein Rab-4A (EC 3.6.5.2)
Gene: RAB4A

Interactor 2: GDIA (P31150)
Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) (Oligophrenin-2) (Protein XAP-4)
Gene: GDI1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	26496610, 28514442, 33961781, 35271311, 34079125, 19570034
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	GDI~Ras
Common GO terms	GO:0015031 - protein transport GO:0016192 - vesicle-mediated transport GO:0032482 - Rab protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 218 Hs			1 447
+	Hs
		678338 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		GDIA_HUMAN (1-447): 0: 724: 100.00
+	Hs
		678381 RAB8B_HUMAN (6-205): 1.17e-89: 264: 42.00		GDIA_HUMAN (1-447): 0: 724: 100.00
+	Hs
		678344 RAB1A_HUMAN (3-218): 3.01e-85: 252: 38.43		GDIA_HUMAN (1-447): 0: 724: 100.00
+	Mm
		838709 RAB1A_MOUSE (3-218): 3.01e-85: 252: 38.43		GDIA_MOUSE (1-447): 0: 722: 97.99
+	Hs
		838617 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		GDIB_HUMAN (1-444): 0: 700: 86.49
+	Hs
		838673 RAB8B_HUMAN (6-205): 1.17e-89: 264: 42.00		GDIB_HUMAN (1-444): 0: 700: 86.49
+	Hs
		591772 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		GDIB_HUMAN (1-444): 0: 700: 86.49
+	Hs
		838625 RAB1A_HUMAN (3-218): 3.01e-85: 252: 38.43		GDIB_HUMAN (1-444): 0: 700: 86.49
+	Dm
		1197044 Q86BK8_DROME (3-218): 6.99e-93: 273: 56.94		Q9VLB7_DROME (1-440): 0: 657: 67.80
+	At
		656917 RAE1C_ARATH (9-217): 4.89e-87: 257: 40.00		REP_ARATH (2-433): 2.71e-90: 286: 20.26
+	Ce
		92107 O01577_CAEEL (9-206): 1.84e-89: 264: 54.04		E9P8A8_CAEEL (342-436): 3.79e-39: 138: 54.74
+	Hs
		622571 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RAE1_HUMAN (1-72): 1.02e-13: 75: 33.33
+	Hs
		642719 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RAE2_HUMAN (1-47): 1.95e-13: 74.3: 44.68
+	Hs
		622608 RAB8B_HUMAN (6-205): 1.17e-89: 264: 42.00		RAE1_HUMAN (1-72): 1.02e-13: 75: 33.33
+	Hs
		642738 RAB8B_HUMAN (6-205): 1.17e-89: 264: 42.00		RAE2_HUMAN (1-47): 1.95e-13: 74.3: 44.68
+	Hs
		591739 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		RAE1_HUMAN (1-72): 1.02e-13: 75: 33.33
+	Hs
		591740 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		RAE2_HUMAN (1-47): 1.95e-13: 74.3: 44.68
+	Hs
		622577 RAB1A_HUMAN (3-218): 3.01e-85: 252: 38.43		RAE1_HUMAN (1-72): 1.02e-13: 75: 33.33
+	Hs
		642723 RAB1A_HUMAN (3-218): 3.01e-85: 252: 38.43		RAE2_HUMAN (1-47): 1.95e-13: 74.3: 44.68
+	Hs
		622574 RAB14_HUMAN (3-217): 2.42e-84: 250: 57.21		RAE1_HUMAN (1-72): 1.02e-13: 75: 33.33