HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28242625
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Hist_deacetyl~Histone
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019899 - enzyme binding GO:0031507 - heterochromatin formation GO:0042393 - histone binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 488
+	Hs
		1368066 H2A1A_HUMAN (1-125): 8.29e-67: 200: 92.00		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1162852 H2A2C_HUMAN (1-129): 5.12e-65: 195: 90.70		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		277760 H2AY_HUMAN (1-142): 1.75e-61: 194: 60.69		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1110006 H2A1A_HUMAN (1-125): 8.29e-67: 200: 92.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1109819 H2A2A_HUMAN (1-129): 7.03e-66: 197: 91.47		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		418970 H2A1B_HUMAN (1-129): 8.38e-66: 197: 90.70		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		502345 H2A1_HUMAN (1-129): 7.6e-66: 197: 91.47		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		277681 H2AY_HUMAN (1-142): 1.75e-61: 194: 60.69		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		188344 H2A1A_HUMAN (1-125): 8.29e-67: 200: 92.00		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	At
		307559 H2A3_ARATH (1-129): 1.15e-61: 187: 71.54		HDA6_ARATH (1-467): 0: 578: 57.02
+	Sp
		148998 H2A2_SCHPO (1-121): 5.18e-53: 165: 83.74		PHD1_SCHPO (7-411): 0: 519: 52.56
+	Mm
		1240199 H2AY_MOUSE (1-142): 1.04e-61: 195: 60.69		HDAC4_MOUSE (1-377): 6.15e-133: 412: 23.89
+	Hs
		591870 H2AX_HUMAN (1-143): 3.73e-74: 219: 100.00		HDAC6_HUMAN (11-363): 6.97e-102: 332: 24.04
+	Sc
		419481 H2A1_YEAST (16-142): 1.37e-53: 166: 75.59		HDA1_YEAST (9-330): 1.24e-121: 373: 27.56
+	Sc
		419831 H2A2_YEAST (16-124): 4.63e-53: 165: 82.57		HDA1_YEAST (9-330): 1.24e-121: 373: 27.56
+	Hs
		419252 H2A1B_HUMAN (1-129): 8.38e-66: 197: 90.70		HDAC6_HUMAN (11-363): 6.97e-102: 332: 24.04
+	Hs
		502578 H2A1_HUMAN (1-129): 7.6e-66: 197: 91.47		HDAC6_HUMAN (11-363): 6.97e-102: 332: 24.04