Protein: HDA1
Histone deacetylase HDA1 (EC 3.5.1.98)

Gene: HDA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 43
UniProt ID: P53973

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003682 - chromatin binding
GO:0040029 - epigenetic regulation of gene expression

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

925461

HDA1
Histone deacetylase HDA1

5

16

Small-scale

0.931

High

925464

HDA3
HDA1 complex subunit 3

6

0

Small-scale

0.904

High

925465

HDA2
HDA1 complex subunit 2

6

0

Small-scale

0.904

High

925469

H2AZ
Histone H2A.Z

2

14

Small-scale

0.806

High

649998

SIN3
Transcriptional regulatory protein SIN3

1

19

Small-scale

0.680

High

844479

GZF3
Protein GZF3

3

16

High-throughput

0.647

High

381204

H2B1
Histone H2B.1

1

20

Small-scale

0.647

High

419481

H2A1
Histone H2A.1

1

13

Small-scale

0.647

High

684917

DAL80
Nitrogen regulatory protein DAL80

2

16

High-throughput

0.590

High

550069

RAP1
DNA-binding protein RAP1

1

0

Small-scale

0.586

High

925462

H3
Histone H3

1

19

Small-scale

0.579

High

682930

MSH2
DNA mismatch repair protein MSH2

2

3

High-throughput

0.567

High

598425

TUP1
General transcriptional corepressor TUP1

1

20

Small-scale

0.561

High

382267

H4
Histone H4

2

12

Small-scale

0.534

High

594504

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.533

High

381589

H2B2
Histone H2B.2

1

20

High-throughput

0.514

High

419831

H2A2
Histone H2A.2

1

13

High-throughput

0.514

High

527401

HSP72
Heat shock protein SSA2

2

18

High-throughput

0.504

High

602597

PHO85
Cyclin-dependent protein kinase PHO85

1

6

High-throughput

0.501

High

545867

SSB1
Ribosome-associated molecular chaperone SSB1

1

19

High-throughput

0.489

High

925468

IF6
Eukaryotic translation initiation factor 6

1

3

High-throughput

0.489

High

778832

PMIP
Mitochondrial intermediate peptidase

1

1

High-throughput

0.470

High

824708

PTPA1
Serine/threonine-protein phosphatase 2A activator 1

1

2

High-throughput

0.464

High

925467

SMT3
Ubiquitin-like protein SMT3

1

4

High-throughput

0.464

High

692418

KCC1
Calcium/calmodulin-dependent protein kinase I

1

12

High-throughput

0.457

High

850960

TOS3
Serine/threonine-protein kinase TOS3

1

9

High-throughput

0.457

High

704639

SBA1
Co-chaperone protein SBA1

1

1

Small-scale

0.439

High

707872

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

735102

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.437

High

776631

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.437

High

812551

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

826730

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

925470

VPS5
Vacuolar protein sorting-associated protein 5

1

2

High-throughput

0.417

High

524811

HSP71
Heat shock protein SSA1

1

18

High-throughput

0.407

High

807118

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.407

High

819472

SSB2
Ribosome-associated molecular chaperone SSB2

1

19

High-throughput

0.407

High

858283

ARC1
tRNA-aminoacylation cofactor ARC1

1

0

High-throughput

0.269

Low

925466

RUP1
UBA domain-containing protein RUP1

1

0

High-throughput

0.269

Low

803345

SHU1
Suppressor of HU sensitivity involved in recombination protein 1

1

0

High-throughput

0.265

Low

817196

CHZ1
Histone H2A.Z-specific chaperone CHZ1

1

0

High-throughput

0.249

Low

925463

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.249

Low

590696

HSP26
Heat shock protein 26

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025