HitPredict

Interactor 1: PRI2 (P20457)
DNA primase large subunit (DNA polymerase alpha:primase complex p58 subunit) (DNA polymerase-primase complex p58 subunit) (Pol alpha-primase complex p58 subunit) (DNA primase 58 kDa subunit)
Gene: PRI2

Interactor 2: DPOE (P21951)
DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase II subunit A)
Gene: POL2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.857

Property	Details
Experiments	6376490, 3888995, 2037567
Identification Methods	affinity chromatography technology, coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DNA_pol_B~DNA_primase_lrg
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006302 - double-strand break repair GO:0051539 - 4 iron, 4 sulfur cluster binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 528 Sc			1 2222
+	Sc
		526816 PRI2_YEAST (1-528): 0: 704: 100.00		DPOLA_YEAST (231-637): 1.77e-77: 287: 10.92
+	Hs
		456101 PRI2_HUMAN (55-522): 0: 601: 35.31		DPOLA_HUMAN (89-635): 1.09e-97: 351: 12.42
+	Sp
		251838 PRI2_SCHPO (55-507): 0: 519: 43.53		DPOLA_SCHPO (213-636): 2.62e-73: 273: 12.88