HitPredict

Interactor 1: H15 (P16401)
Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)
Gene: H1-5

Interactor 2: CCNE1 (P24864)
G1/S-specific cyclin-E1
Gene: CCNE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	15670215, 15514162, 19318554, 8662825
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 226 Hs			1 410
+	Hs
		666977 H11_HUMAN (1-186): 2.9e-15: 73.6: 61.29		CCNE1_HUMAN (1-410): 2.37e-135: 395: 100.00
+	Rn
		73331 H11_RAT (1-123): 2.64e-19: 84.4: 65.85		B1WC54_RAT (1-408): 4.28e-125: 369: 79.95
+	Hs
		595310 H15_HUMAN (1-118): 3.3e-18: 81.7: 100.00		CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58
+	Hs
		595392 H15_HUMAN (1-118): 3.3e-18: 81.7: 100.00		CCNA1_HUMAN (15-367): 4.43e-96: 297: 20.98
+	Hs
		629105 H11_HUMAN (1-186): 2.9e-15: 73.6: 61.29		CCNA2_HUMAN (2-369): 1.62e-99: 304: 20.58
+	Rn
		93226 H11_RAT (1-123): 2.64e-19: 84.4: 65.85		CCNA1_RAT (4-369): 3.46e-95: 293: 21.12
+	Hs
		573745 H15_HUMAN (1-118): 3.3e-18: 81.7: 100.00		CCNB1_HUMAN (1-365): 5.58e-95: 293: 18.82
+	Hs
		1007625 H11_HUMAN (1-186): 2.9e-15: 73.6: 61.29		CCNA1_HUMAN (15-367): 4.43e-96: 297: 20.98
+	Hs
		355345 H11_HUMAN (1-186): 2.9e-15: 73.6: 61.29		CCNE2_HUMAN (4-402): 7.39e-97: 297: 47.38
+	Hs
		573805 H11_HUMAN (1-186): 2.9e-15: 73.6: 61.29		CCNB1_HUMAN (1-365): 5.58e-95: 293: 18.82
+	Mm
		666786 H11_MOUSE (1-124): 1.01e-14: 72.1: 67.74		CCNB1_MOUSE (4-362): 8.44e-94: 290: 18.33