Protein: CCNE1
G1/S-specific cyclin-E1

Gene: CCNE1
Organism: Homo sapiens
Interactions: 114
UniProt ID: P24864

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000723 - telomere maintenance
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

666939

CDK2
Cyclin-dependent kinase 2

60

20

Small-scale

0.997

High

666961

CDN1B
Cyclin-dependent kinase inhibitor 1B

25

20

Small-scale

0.991

High

666957

CDN1A
Cyclin-dependent kinase inhibitor 1

21

20

Small-scale

0.988

High

443188

CDK1
Cyclin-dependent kinase 1

5

20

Small-scale

0.915

High

666973

CDK3
Cyclin-dependent kinase 3

4

20

High-throughput

0.903

High

666964

CDK7
Cyclin-dependent kinase 7

3

20

High-throughput

0.861

High

666975

CDK5
Cyclin-dependent kinase 5

3

20

High-throughput

0.861

High

667004

FBXW7
F-box/WD repeat-containing protein 7

27

5

Small-scale

0.768

High

549055

CDK4
Cyclin-dependent kinase 4

2

20

Small-scale

0.768

High

666974

CDK6
Cyclin-dependent kinase 6

2

20

Small-scale

0.768

High

666977

H11
Histone H1.1

11

11

Small-scale

0.757

High

442593

RB
Retinoblastoma-associated protein

9

12

Small-scale

0.751

High

666988

CUL3
Cullin-3

4

6

Small-scale

0.690

High

595318

H15
Histone H1.5

4

11

Small-scale

0.688

High

667023

ARI1
E3 ubiquitin-protein ligase ARIH1

4

3

Small-scale

0.683

High

240784

PRKN
E3 ubiquitin-protein ligase parkin

3

6

Small-scale

0.678

High

550848

PCNA
Proliferating cell nuclear antigen

3

3

High-throughput

0.667

High

666992

NPAT
Protein NPAT

3

1

Small-scale

0.656

High

666948

MPIP1
M-phase inducer phosphatase 1

3

11

Small-scale

0.651

High

169955

AURKA
Aurora kinase A

1

5

High-throughput

0.647

High

666938

CCNE1
G1/S-specific cyclin-E1

1

5

High-throughput

0.647

High

666947

CCND2
G1/S-specific cyclin-D2

1

5

High-throughput

0.647

High

666950

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

High-throughput

0.647

High

666962

GSK3B
Glycogen synthase kinase-3 beta

1

20

Small-scale

0.647

High

666995

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.647

High

667014

LATS2
Serine/threonine-protein kinase LATS2

1

5

High-throughput

0.647

High

667007

UHRF2
E3 ubiquitin-protein ligase UHRF2

2

2

Small-scale

0.646

High

666976

E2F1
Transcription factor E2F1

3

11

Small-scale

0.640

High

666978

FOXM1
Forkhead box protein M1

2

2

Small-scale

0.639

High

227377

SPOP
Speckle-type POZ protein

2

2

Small-scale

0.634

High

666951

CKS2
Cyclin-dependent kinases regulatory subunit 2

2

20

High-throughput

0.628

High

666970

CKS1
Cyclin-dependent kinases regulatory subunit 1

2

20

High-throughput

0.628

High

666965

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.618

High

666998

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

4

High-throughput

0.618

High

666985

SKP2
S-phase kinase-associated protein 2

2

6

Small-scale

0.602

High

667021

FBW1A
F-box/WD repeat-containing protein 1A

2

5

Small-scale

0.602

High

666987

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.586

High

666967

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

5

Small-scale

0.584

High

666979

RBL2
Retinoblastoma-like protein 2

2

12

Small-scale

0.584

High

64629

GEMC1
Geminin coiled-coil domain-containing protein 1

2

0

High-throughput

0.580

High

667006

LIN37
Protein lin-37 homolog

2

0

High-throughput

0.576

High

322699

RHBT3
Rho-related BTB domain-containing protein 3

1

2

Small-scale

0.561

High

666940

MCM3
DNA replication licensing factor MCM3

1

6

Small-scale

0.561

High

666943

DPOD1
DNA polymerase delta catalytic subunit

1

4

Small-scale

0.561

High

666949

MPIP3
M-phase inducer phosphatase 3

1

11

Small-scale

0.561

High

666952

CTNB1
Catenin beta-1

1

6

Small-scale

0.561

High

667018

HERC5
E3 ISG15--protein ligase HERC5

1

4

Small-scale

0.561

High

186702

P73
Tumor protein p73

1

4

Small-scale

0.536

High

666953

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.536

High

666991

TFDP2
Transcription factor Dp-2

1

7

High-throughput

0.536

High

666981

ARHG5
Rho guanine nucleotide exchange factor 5

1

0

High-throughput

0.518

High

666955

BRCA1
Breast cancer type 1 susceptibility protein

1

2

Small-scale

0.515

High

666963

MRE11
Double-strand break repair protein MRE11

1

1

Small-scale

0.515

High

222730

PRC1
Protein regulator of cytokinesis 1

1

3

Small-scale

0.501

High

371191

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.501

High

455698

H10
Histone H1.0

1

1

Small-scale

0.501

High

519460

MYBB
Myb-related protein B

1

3

Small-scale

0.501

High

604600

UBF1
Nucleolar transcription factor 1

1

2

Small-scale

0.501

High

666945

ARI4A
AT-rich interactive domain-containing protein 4A

1

3

Small-scale

0.501

High

666958

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

High-throughput

0.501

High

666959

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

2

High-throughput

0.501

High

666960

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

3

High-throughput

0.501

High

666993

IMB1
Importin subunit beta-1

1

2

Small-scale

0.501

High

666999

TSC1
Hamartin

1

2

High-throughput

0.501

High

667001

KAT2A
Histone acetyltransferase KAT2A

1

10

High-throughput

0.501

High

667008

CDC6
Cell division control protein 6 homolog

1

8

Small-scale

0.501

High

667010

GLIS2
Zinc finger protein GLIS2

1

2

High-throughput

0.501

High

667015

RASF1
Ras association domain-containing protein 1

1

1

High-throughput

0.501

High

667019

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.501

High

262018

NBN
Nibrin

1

0

Small-scale

0.493

High

162907

TERT
Telomerase reverse transcriptase

1

0

High-throughput

0.480

High

666942

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.480

High

666946

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

Small-scale

0.480

High

666954

MERL
Merlin

1

0

High-throughput

0.480

High

666956

COIL
Coilin

1

0

Small-scale

0.480

High

666984

GRM1
Metabotropic glutamate receptor 1

1

0

High-throughput

0.480

High

666994

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.480

High

667017

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

1

0

Small-scale

0.480

High

67125

UBP27
Ubiquitin carboxyl-terminal hydrolase 27

1

3

Small-scale

0.479

High

175838

SET1A
Histone-lysine N-methyltransferase SETD1A

1

1

Small-scale

0.479

High

487975

DPOLA
DNA polymerase alpha catalytic subunit

1

4

Small-scale

0.479

High

507540

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

Small-scale

0.479

High

519750

ANDR
Androgen receptor

1

1

Small-scale

0.479

High

531001

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

1

Small-scale

0.479

High

568760

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

Small-scale

0.479

High

666941

NFYB
Nuclear transcription factor Y subunit beta

1

2

Small-scale

0.479

High

666944

RBL1
Retinoblastoma-like protein 1

1

12

Small-scale

0.479

High

666966

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

5

Small-scale

0.479

High

666968

HCFC1
Host cell factor 1

1

1

Small-scale

0.479

High

666969

PSA6
Proteasome subunit alpha type-6

1

3

Small-scale

0.479

High

666971

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

666980

EP300
Histone acetyltransferase p300

1

8

Small-scale

0.479

High

666982

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.479

High

666983

KLF10
Krueppel-like factor 10

1

3

Small-scale

0.479

High

666986

BIRC2
Baculoviral IAP repeat-containing protein 2

1

5

Small-scale

0.479

High

666989

CUL4B
Cullin-4B

1

6

Small-scale

0.479

High

666990

TFDP1
Transcription factor Dp-1

1

7

Small-scale

0.479

High

666996

E2F4
Transcription factor E2F4

1

11

Small-scale

0.479

High

667000

CBP
CREB-binding protein

1

6

Small-scale

0.479

High

667003

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

1

Small-scale

0.479

High

667005

OTUB1
Ubiquitin thioesterase OTUB1

1

1

Small-scale

0.479

High

667011

CDT1
DNA replication factor Cdt1

1

3

Small-scale

0.479

High

667013

TRI36
E3 ubiquitin-protein ligase TRIM36

1

8

Small-scale

0.479

High

667016

CISH
Cytokine-inducible SH2-containing protein

1

2

Small-scale

0.479

High

667020

PHF8
Histone lysine demethylase PHF8

1

1

Small-scale

0.479

High

667022

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

1

Small-scale

0.479

High

285803

SF3B1
Splicing factor 3B subunit 1

1

0

Small-scale

0.458

High

666972

TCPB
T-complex protein 1 subunit beta

1

0

Small-scale

0.458

High

666997

STX12
Syntaxin-12

1

0

High-throughput

0.458

High

667002

SMRC1
SWI/SNF complex subunit SMARCC1

1

0

Small-scale

0.458

High

667009

AKAP9
A-kinase anchor protein 9

1

0

Small-scale

0.458

High

648422

FGFR4
Fibroblast growth factor receptor 4

1

2

High-throughput

0.457

High

667012

DJC18
DnaJ homolog subfamily C member 18

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025